Ito N, Fukushima S, Shirai T, Hagiwara A, Imaida K
IARC Sci Publ. 1984(56):399-407.
The promoting effects of various chemicals on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were studied. Male Fischer 344 rats were given BBN at 0.01% or 0.05% in their drinking-water for four weeks. One of the following chemicals was then administered in the diet for 32 or 34 weeks: acetazolamide, allopurinol, phenobarbital, phenacetin, ortho-phenylphenol, sodium ortho-phenylphenate, diphenyl, sodium L-ascorbate, butylated hydroxyanisole, butylated hydroxytoluene, sodium saccharin, aspartame, sodium cyclamate, stevioside, DL-tryptophan, quercetin, caffeine, nicotine and hippuric acid. Phenacetin, sodium ortho-phenylphenate, sodium L-ascorbate and butylated hydroxyanisole were significant promoters of urinary bladder neoplasia in rats initiated with BBN. Sodium saccharin, diphenyl, butylated hydroxytoluene, allopurinol, and DL-tryptophan caused moderate or slight promotion of neoplastic changes in the experimental animals. No change in tumour yield was observed after administration of the other chemicals.
研究了多种化学物质对用N-丁基-N-(4-羟基丁基)亚硝胺（BBN）启动的大鼠膀胱致癌作用的促进效果。将雄性Fischer 344大鼠的饮用水中加入0.01%或0.05%的BBN，持续四周。然后在接下来的32或34周内，在饮食中添加以下化学物质之一：乙酰唑胺、别嘌醇、苯巴比妥、非那西丁、邻苯基苯酚、邻苯基苯酚钠、联苯、L-抗坏血酸钠、丁基羟基茴香醚、二丁基羟基甲苯、糖精钠、阿斯巴甜、环己基氨基磺酸钠、甜菊糖苷、DL-色氨酸、槲皮素、咖啡因、尼古丁和马尿酸。非那西丁、邻苯基苯酚钠、L-抗坏血酸钠和丁基羟基茴香醚是用BBN启动的大鼠膀胱肿瘤形成的显著促进剂。糖精钠、联苯、二丁基羟基甲苯、别嘌醇和DL-色氨酸对实验动物的肿瘤变化有中度或轻度促进作用。给予其他化学物质后未观察到肿瘤发生率的变化。
