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糖尿病犬的肾血管阻力异常：与血糖状态和蛋白尿的相关性。

Abnormal renovascular resistance in dogs with diabetes mellitus: correlation with glycemic status and proteinuria.

作者信息

Priyanka M, Jeyaraja K, Thirunavakkarasu P S

机构信息

Animal Experimentation Station, Indian Veterinary Research Institute, Regional Campus, Bengaluru, Karnataka, 560024, India.

Department of Clinics, Madras Veterinary College, TANUVAS, Chennai-600007, India.

出版信息

Iran J Vet Res. 2018 Fall;19(4):304-309.

PMID:30774672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6361597/
Abstract

Present study was conducted with the objectives of determining the renal vascular resistance in dogs with diabetes mellitus and to study the correlation between the indices of renovascular resistance with glycemic status, systolic blood pressure (SBP) and proteinuria in dogs with diabetes mellitus. This study was conducted on seventeen diabetic dogs and ten apparently healthy dogs. Increased renal resistive index (RI) and pulsatility index (PI) were observed in diabetic dogs as compared to healthy dogs. Systemic hypertension and proteinuria were observed in 10 and 3 out of 17 diabetic dogs, respectively. Significant positive correlation was observed between the indices of renovascular resistance and fasting blood glucose levels and between the indices of renovascular resistance and serum glycated hemoglobin levels. No correlation was observed between the indices of renovascular resistance and SBP as well as the indices of renovascular resistance and proteinuria. As the indices of renovascular resistance correlate significantly with glycemic status, they can be used as the early marker for kidney damage in diabetic patients. Among these indices renal PI was found to be more sensitive than renal RI.

摘要

本研究旨在测定糖尿病犬的肾血管阻力，并研究糖尿病犬肾血管阻力指标与血糖状态、收缩压（SBP）及蛋白尿之间的相关性。本研究选取了17只糖尿病犬和10只看似健康的犬。与健康犬相比，糖尿病犬的肾阻力指数（RI）和搏动指数（PI）升高。17只糖尿病犬中，分别有10只出现系统性高血压，3只出现蛋白尿。肾血管阻力指标与空腹血糖水平之间以及肾血管阻力指标与血清糖化血红蛋白水平之间存在显著正相关。肾血管阻力指标与SBP以及肾血管阻力指标与蛋白尿之间未观察到相关性。由于肾血管阻力指标与血糖状态显著相关，它们可作为糖尿病患者肾损伤的早期标志物。在这些指标中，发现肾PI比肾RI更敏感。