Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada; Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
KITE - Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Neurobiol Aging. 2024 Mar;135:15-25. doi: 10.1016/j.neurobiolaging.2023.12.004. Epub 2023 Dec 19.
Impaired angiogenesis is associated with cognitive decline in older adults. While exercise has been broadly associated with increased angiogenesis, the relevant mechanisms in older adults are not clear. Here, we present a systematic review and meta-analysis on the relationship between exercise and specific blood angiogenesis markers in older adults to better understand the relevant mechanisms. MEDLINE, Embase, and Cochrane CENTRAL were searched for original reports of angiogenesis markers' concentrations in blood before and after exercise in older adults (≥50 years). Heterogeneity was investigated using sub-group analyses and meta-regressions. Of the 44 articles included in the review, 38 were included in the meta-analyses for five markers: vascular endothelial growth factor (VEGF), e-selectin (CD62E), endostatin, fibroblast growth factor 2, and matrix metallopeptidase-9. VEGF levels were higher (SMD[95%CI]= 0.18[0.03, 0.34], and CD62E levels were lower (SMD[95%CI]= -0.72[-1.42, -0.03], p = 0.04) after exercise. No other markers were altered. Although more studies are needed, changes in angiogenesis markers may help explain the beneficial effects of exercise on angiogenesis in older adults.
血管生成受损与老年人的认知能力下降有关。虽然运动与血管生成增加广泛相关，但老年人中相关的机制尚不清楚。在这里，我们对运动与老年人血液中特定血管生成标志物之间的关系进行了系统评价和荟萃分析，以更好地理解相关机制。我们在 MEDLINE、Embase 和 Cochrane CENTRAL 中搜索了老年人运动前后血液中血管生成标志物浓度的原始报告（≥50 岁）。使用亚组分析和荟萃回归来研究异质性。在综述中纳入的 44 篇文章中，有 38 篇纳入了 5 种标志物的荟萃分析：血管内皮生长因子（VEGF）、E-选择素（CD62E）、内皮抑素、成纤维细胞生长因子 2 和基质金属蛋白酶 9。运动后 VEGF 水平升高（SMD[95%CI]=0.18[0.03, 0.34]），CD62E 水平降低（SMD[95%CI]=-0.72[-1.42, -0.03]，p=0.04）。其他标志物没有变化。尽管还需要更多的研究，但血管生成标志物的变化可能有助于解释运动对老年人血管生成的有益影响。
