Bazyar Hadi, Maghsoumi-Norouzabad Leila, Yarahmadi Mohsen, Gholinezhad Hassan, Moradi Leila, Salehi Parvin, Haghighi-Zadeh Mohammad Hosein, Zare Javid Ahmad
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Diabetes Metab Syndr Obes. 2020 Jan 6;13:19-29. doi: 10.2147/DMSO.S230060. eCollection 2020.
The aim of the current study was to investigate that combination of the synbiotic supplementation in adjunct with non-surgical periodontal therapy (NSPT) is useful in treating periodontitis and biomarkers of oxidative stress in type 2 diabetes mellitus (T2DM) patients.
In this study, 47 patients suffering from DM and CP were recruited and randomly assigned to two groups. The intervention (n= 23) and control (n=24) groups received either multispecies probiotic supplement plus 100 mg fructo-oligosaccharide (500 mg in each capsule) or placebo capsule containing 500 mg wheat flour, respectively, every day for 8 weeks. All subjects were treated with NSPT during the intervention period. Serum levels of interleukin-1β (IL-1β), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and periodontal indices including clinical attachment loss (CAL), pocket depth (PD) (main outcome), BOP, and plaque index were measured before and after the intervention.
Supplementation with the synbiotic with NSPT led to a significant decrease in the levels of IL-1β, MDA, plaque index, PD, and CAL in the intervention group post-intervention (p < 0.05). The serum levels of TAC, SOD, and GPx were significantly increased in the intervention group compared with the baseline (p < 0.05). Consumption of synbiotic with NSPT, compared to the control, resulted in a significant decrease in the mean changes of IL-1β, MDA, and CAL (p < 0.05). Also, the mean changes of TAC and GPx were significantly higher in the intervention group compared with the control group (p < 0.05). Also, in the intervention group was seen a significant reduction in plaque index (p = 0.035) and BOP (p = 0.04) compared with the control group.
It was observed that synbiotic supplementation with NSPT may be beneficial in improving inflammatory, antioxidant, and periodontal status in T2DM patients with CP.
本研究旨在探讨在非手术牙周治疗（NSPT）的基础上联合补充合生元对2型糖尿病（T2DM）患者牙周炎及氧化应激生物标志物的治疗效果。
本研究招募了47例患有糖尿病和慢性牙周炎（CP）的患者，并将其随机分为两组。干预组（n = 23）和对照组（n = 24）分别每天服用多种益生菌补充剂加100毫克低聚果糖（每粒胶囊含500毫克）或含500毫克小麦粉的安慰剂胶囊，持续8周。在干预期间，所有受试者均接受NSPT治疗。在干预前后测量血清白细胞介素-1β（IL-1β）、丙二醛（MDA）、总抗氧化能力（TAC）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）水平以及牙周指标，包括临床附着丧失（CAL）、牙周袋深度（PD）（主要观察指标）、探诊出血（BOP）和菌斑指数。
干预组在干预后补充合生元联合NSPT导致IL-1β、MDA、菌斑指数、PD和CAL水平显著降低（p < 0.05）。与基线相比，干预组血清TAC、SOD和GPx水平显著升高（p < 0.05）。与对照组相比，补充合生元联合NSPT导致IL-1β、MDA和CAL的平均变化显著降低（p < 0.05）。此外，干预组TAC和GPx的平均变化显著高于对照组（p < 0.05）。而且，与对照组相比，干预组的菌斑指数（p = 0.035）和BOP（p = 0.04）显著降低。
观察到补充合生元联合NSPT可能有助于改善患有CP的T2DM患者的炎症、抗氧化和牙周状况。
