Department of Molecular Microbiology and Immunology, University of Missouri-School of Medicine, Columbia, Missouri, United States of America.
Center of Agroforestry, School of Natural Resources, University of Missouri, Columbia, Missouri, United States of America.
PLoS Pathog. 2023 Dec 28;19(12):e1011688. doi: 10.1371/journal.ppat.1011688. eCollection 2023 Dec.
Deep sequencing of wastewater to detect SARS-CoV-2 has been used during the COVID-19 pandemic to monitor viral variants as they appear and circulate in communities. SARS-CoV-2 lineages of an unknown source that have not been detected in clinical samples, referred to as cryptic lineages, are sometimes repeatedly detected from specific locations. We have continued to detect one such lineage previously seen in a Missouri site. This cryptic lineage has continued to evolve, indicating continued selective pressure similar to that observed in Omicron lineages.
利用废水进行深度测序来检测 SARS-CoV-2，在 COVID-19 大流行期间已被用于监测病毒变种，以便及时发现和了解其在社区中的传播情况。有些 SARS-CoV-2 谱系源自未知来源，在临床样本中尚未检测到，被称为隐匿谱系，有时会在特定地点反复被检出。我们之前在密苏里州的一个地点就曾检测到过此类谱系。该隐匿谱系持续进化，表明持续存在类似于奥密克戎谱系的选择压力。
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