美国成年人群中环氧乙烷暴露与肝功能之间的关联。
Associations between Ethylene Oxide Exposure and Liver Function in the US Adult Population.
作者信息
Li Shanshan, Wang Jinzhou, Lei Dengliang, Peng Dadi, Zong Kezhen, Li Kaili, Wu Zhongjun, Liu Yanyao, Huang Zuotian
机构信息
First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.
Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
出版信息
Toxics. 2024 Jul 30;12(8):551. doi: 10.3390/toxics12080551.
BACKGROUND
Ethylene oxide, a reactive epoxy compound, has been widely used in various industries for many years. However, evidence of the combined toxic effects of ethylene oxide exposure on the liver is still lacking.
METHODS
We analyzed the merged data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016. Ultimately, 4141 adults aged 18 and over were selected as the sample. We used linear regression to explore the association between blood ethylene oxide and LFT indicators.
RESULTS
The weighted linear regression model showed that HbEO is positively correlated with ALP ( = 2.61, 95% CI 1.97, 3.24, < 0.0001), GGT ( = 5.75, 95% CI 4.46, 7/05, < 0.0001), ALT ( = 0.50, 95% CI 0.09, 0.90, = 0.0158), and AST ( = 0.71, 95% CI 0.44, 0.98, < 0.0001) and negatively correlated with TBIL ( = -0.30, 95% CI -0.43, -0.16, < 0.0001).
CONCLUSIONS
Ethylene oxide exposure is significantly associated with changes in liver function indicators among adults in the United States. Future work should further examine these relationships.
背景
环氧乙烷是一种活性环氧化合物，多年来已在各个行业中广泛使用。然而，环氧乙烷暴露对肝脏的联合毒性作用的证据仍然缺乏。
方法
我们分析了2013年至2016年美国国家健康与营养检查调查（NHANES）的合并数据。最终，选择了4141名18岁及以上的成年人作为样本。我们使用线性回归来探索血液环氧乙烷与肝功能指标之间的关联。
结果
加权线性回归模型显示，血液环氧乙烷水平（HbEO）与碱性磷酸酶（β = 2.61，95%置信区间1.97，3.24，P < 0.0001）、γ-谷氨酰转移酶（β = 5.75，95%置信区间4.46，7.05，P < 0.0001）、谷丙转氨酶（β = 0.50，95%置信区间0.09，0.90，P = 0.0158）和谷草转氨酶（β = 0.71，95%置信区间0.44，0.98，P < 0.0001）呈正相关，与总胆红素（β = -0.30，95%置信区间-0.43，-0.16，P < 0.0001）呈负相关。
结论
在美国成年人中，环氧乙烷暴露与肝功能指标的变化显著相关。未来的工作应进一步研究这些关系。
Zotero 插件