Toxicology Department, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.
Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China.
Biol Trace Elem Res. 2024 Sep;202(9):4158-4169. doi: 10.1007/s12011-023-03999-0. Epub 2023 Dec 29.
Manganese (Mn) is a heavy metal that occurs widely in nature and has a vital physiological role in growth and development. However, excessive exposure to Mn can cause neurological damage, especially cognitive dysfunction, such as learning disability and memory loss. Numerous studies on the mechanisms of Mn-induced nervous system damage found that this metal targets a variety of metabolic pathways, for example, endoplasmic reticulum stress, apoptosis, neuroinflammation, cellular signaling pathway changes, and neurotransmitter metabolism interference. This article reviews the latest research progress on multiple signaling pathways related to Mn-induced neurological dysfunction.
锰（Mn）是一种广泛存在于自然界中的重金属，在生长发育中具有重要的生理作用。然而，过量暴露于锰会导致神经系统损伤，特别是认知功能障碍，如学习障碍和记忆力丧失。大量关于锰诱导的神经系统损伤机制的研究发现，这种金属会针对多种代谢途径，例如内质网应激、细胞凋亡、神经炎症、细胞信号通路变化以及神经递质代谢干扰。本文综述了与锰诱导的神经功能障碍相关的多种信号通路的最新研究进展。
