Kubens Laura, Truong Khai-Nghi, Lehmann Christian W, Lützenkirchen-Hecht Dirk, Bornhorst Julia, Mohr Fabian
Anorganische Chemie, Bergische Universität Wuppertal, Gaußstraße 20, 42119, Wuppertal, Germany.
Lebensmittelchemie, Bergische Universität Wuppertal, Gaußstraße 20, 42119, Wuppertal, Germany.
Chemistry. 2023 Oct 2;29(55):e202301721. doi: 10.1002/chem.202301721. Epub 2023 Aug 29.
Maneb is a manganese(II)-containing fungicide with a multi-site effect and no resistance, therefore it is widely applied in many parts of the world. There is, however, mounting evidence for neurotoxic effects with Parkinson-like symptoms (manganism) related to usage of Maneb. Due to its insolubility in most solvents and its paramagnetism, structural elucidation is not trivial, and thus its exact molecular structure remains unknown. We report herein a synthesis procedure to prepare Maneb reproducibly in pure form and the use of various analytical techniques including X-ray diffraction, X-ray absorption spectroscopy and electron diffraction to determine the molecular structure of Maneb in the solid state and also in solution.
代森锰是一种具有多位点作用且无抗性的含锰（II）杀菌剂，因此在世界许多地区都有广泛应用。然而，越来越多的证据表明，与代森锰的使用相关的帕金森样症状（锰中毒）存在神经毒性作用。由于它在大多数溶剂中不溶且具有顺磁性，其结构解析并非易事，因此其确切的分子结构仍然未知。我们在此报告一种可重复制备纯形式代森锰的合成方法，以及使用包括X射线衍射、X射线吸收光谱和电子衍射在内的各种分析技术来确定代森锰在固态和溶液中的分子结构。
