MacIntyre N R, Ramage J E, Follett J V
Crit Care Med. 1987 Apr;15(4):303-7. doi: 10.1097/00003246-198704000-00004.
Mechanical ventilatory support of bronchoscopic procedures by conventional volume-cycled ventilation (VCV) is technically difficult and can result in unreliable gas delivery or excessive alveolar pressure. An alternate support mode is jet ventilation through an open, uncuffed endotracheal tube. To quantitate gas delivery and airway pressures (Paw) during bronchoscopy using this technique, we used a mechanical-lung model and 15 human subjects. Jet ventilation pulsed gases at 60 to 100 cycle/min through a catheter in an uncuffed, jet endotracheal tube with a 5.9-mm (OD) bronchoscope in place. Inspiratory time was constant at 33% of cycle time, and jet-drive pressures ranged from 5 to 30 psi. In the mechanical-lung model, the jet technique provided up to 30 L/min of ventilation with mean airway pressures (Paw) always less than 10 cm H2O. In contrast, VCV with an inflated cuff, while providing similar levels of ventilation, resulted in substantial air trapping and over twice the Paw. VCV with a deflated cuff provided much lower levels of ventilation, although Paw levels were also low. These delivered minute ventilations, and Paw levels were similar in six normal volunteers jet ventilated through a 9-mm jet endotracheal tube with a bronchoscope in place. Finally, in nine patients requiring mechanical ventilatory support during bronchoscopic procedures, this jet technique provided alveolar ventilation (i.e., PaCO2) and Paw levels comparable to those obtained on baseline VCV before bronchoscopy.
通过传统容量控制通气(VCV)对支气管镜检查进行机械通气支持在技术上具有挑战性,并且可能导致气体输送不可靠或肺泡压力过高。一种替代的支持模式是通过开放的、无套囊气管内导管进行喷射通气。为了在支气管镜检查期间使用该技术定量气体输送和气道压力(Paw),我们使用了一个机械肺模型和15名人类受试者。喷射通气通过一根带有5.9毫米(外径)支气管镜的无套囊喷射气管内导管中的导管,以60至100次/分钟的频率脉冲输送气体。吸气时间恒定为周期时间的33%,喷射驱动压力范围为5至30磅力/平方英寸。在机械肺模型中,喷射技术可提供高达30升/分钟的通气量,平均气道压力(Paw)始终低于10厘米水柱。相比之下,带充气套囊的VCV在提供相似通气水平的同时,会导致大量气体潴留,且Paw是前者的两倍多。带放气套囊的VCV提供的通气水平要低得多,尽管Paw水平也较低。在六名通过带有支气管镜的9毫米喷射气管内导管进行喷射通气的正常志愿者中,这些输送的分钟通气量和Paw水平相似。最后,在九名在支气管镜检查期间需要机械通气支持的患者中,这种喷射技术提供的肺泡通气(即PaCO2)和Paw水平与支气管镜检查前基线VCV时获得的水平相当。