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2021 年丹麦北部地区食管食物团块阻塞的回顾性队列研究——三分之二的患者从未被诊断出病因。

A retrospective cohort study on oesophageal food bolus obstruction in the North Denmark region in 2021-two thirds were never diagnosed with a cause.

机构信息

School of Medicine and Health, Aalborg University, Aalborg, Denmark.

Department of Emergency Medicine and Trauma Center, Aalborg University Hospital, Hobrovej 18-22, DK-9000, Aalborg, Denmark.

出版信息

BMC Gastroenterol. 2024 Jan 2;24(1):3. doi: 10.1186/s12876-023-03077-8.

Abstract

BACKGROUND

Food bolus obstruction (FBO) leading to hospital treatment is often associated with eosinophilic oesophagitis (EoE), stenosis, or oesophageal cancer (1). Danish national guidelines recommend that patients with FBO undergo a diagnostic upper endoscopy within two weeks of presentation to exclude possible malignancy, and histological evaluation of eight biopsies (2, 3).

AIMS

The aims of this study were to (1) report the incidence and describe the causes and treatment of FBO in the North Denmark Region (NDR), (2) determine the proportion of patients who underwent upper endoscopy and biopsy according to regional and national guidelines, and (3) identify International Classification of Diseases 10th Revision (ICD-10) diagnosis and procedure codes applied to the hospital visits due to FBO in the NDR.

METHODS

Among all acute hospital visits in the NDR in 2021, all visits with ICD-10 codes possibly reflecting FBO, as well as a random sample of 14,400 visits with unspecific ICD-10 codes (R and Z codes), were screened manually for possible FBO. Diagnosis, follow-up, and treatment of all patients with FBO were recorded.

RESULTS

The median patient age was 66.0 (Q1-Q3: 49.8-81.0) years, and half of the patients had experienced FBO before. Two thirds of patients (66.0%) were never diagnosed with a cause of FBO, followed by 17.3% with EoE. 30% of patients did not undergo upper endoscopy within two weeks of the hospital visit, and 50.7% were never biopsied in the oesophagus. Of 1886 hospital visits with registry ICD-10 codes that possibly reflected FBO, 8.4% were due to FBO, while FBO was present in 0.028% of the random sample of unspecific ICD-10 codes.

CONCLUSIONS

Most hospitalized FBO patients in the NDR in 2021 were never diagnosed with a cause. In these patients there is a high risk of overlooked EoE or upper gastrointestinal cancers. The area needs immediate focus and changed routines to improve treatment and prevent new FBO.

摘要

背景

食物团块阻塞(FBO)导致住院治疗通常与嗜酸性食管炎(EoE)、狭窄或食管癌有关(1)。丹麦国家指南建议,出现 FBO 的患者应在就诊后两周内进行诊断性上消化道内镜检查,以排除可能的恶性肿瘤,并进行 8 块活检的组织学评估(2,3)。

目的

本研究的目的是:(1)报告在丹麦北日德兰地区(NDR)FBO 的发生率和病因,并描述其治疗方法;(2)根据区域和国家指南,确定接受上消化道内镜检查和活检的患者比例;(3)确定应用于 NDR 因 FBO 就诊的医院就诊的国际疾病分类第 10 次修订版(ICD-10)诊断和程序代码。

方法

在 2021 年 NDR 的所有急性住院就诊中,对可能反映 FBO 的所有就诊均采用 ICD-10 代码进行筛查,并对 14400 次非特异性 ICD-10 代码(R 和 Z 代码)就诊进行随机抽样,手动筛查可能的 FBO。记录所有 FBO 患者的诊断、随访和治疗情况。

结果

患者的中位年龄为 66.0(Q1-Q3:49.8-81.0)岁,其中一半的患者之前曾出现过 FBO。三分之二的患者(66.0%)从未被诊断出 FBO 的病因,其次是 17.3%的患者患有 EoE。30%的患者在就诊后两周内未进行上消化道内镜检查,50.7%的患者从未进行过食管活检。在 1886 次可能反映 FBO 的住院就诊中,有 8.4%是由于 FBO,而在非特异性 ICD-10 代码的随机抽样中,FBO 的发生率为 0.028%。

结论

2021 年 NDR 中大多数住院 FBO 患者从未被诊断出病因。在这些患者中,存在被忽视的 EoE 或上消化道癌症的高风险。该地区需要立即关注并改变常规,以改善治疗效果并预防新的 FBO。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaf9/10759704/e0836b77ca28/12876_2023_3077_Fig1_HTML.jpg

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