Turan Turhan, Akyuz Ali Riza, Aykan Ahmet Cagri, Kul Selim, Cirakoglu Omer Faruk, Aslan Ahmet Oguz, Gul Ilker, Uçar Utku, Demir Selim, Celik Sukru
1 Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey.
2 Department of Cardiology, Izmir Sifa University Hospital, Trabzon, Turkey.
Angiology. 2016 Nov;67(10):932-936. doi: 10.1177/0003319716637789. Epub 2016 Jul 11.
Endocan is a soluble proteoglycan, secreted by human vascular endothelial cells. Endocan is a marker for vascular pathologies and an important mediator of angiogenesis, strongly associated with inflammation, vascular endothelial dysfunction, and atherosclerosis. The relationship between coronary artery ectasia (CAE) and endocan has not been evaluated. We aimed to investigate this association. Fifty-four patients with isolated CAE without coronary stenosis and 30 controls with normal coronary angiogram were included in this study. Endocan plasma concentrations were measured using an enzyme-linked immunosorbent assay. Patients with isolated CAE had significantly higher levels of endocan compared to the controls (18.9 ± 7.3 vs 15.6 ± 3.6 ng/mL; P = .007). There was a significant correlation between endocan levels and severity of isolated CAE according to the Markis classification ( r = -.593, P < .001). Plasma endocan levels may reflect the presence and severity of isolated CAE, suggesting that endocan may be involved in pathogenesis of isolated CAE.
内脂素是一种由人血管内皮细胞分泌的可溶性蛋白聚糖。内脂素是血管病变的标志物，也是血管生成的重要介质，与炎症、血管内皮功能障碍和动脉粥样硬化密切相关。冠状动脉扩张（CAE）与内脂素之间的关系尚未得到评估。我们旨在研究这种关联。本研究纳入了54例无冠状动脉狭窄的孤立性CAE患者和30例冠状动脉造影正常的对照者。采用酶联免疫吸附测定法测量血浆内脂素浓度。与对照组相比，孤立性CAE患者的内脂素水平显著更高（18.9±7.3对15.6±3.6 ng/mL；P = 0.007）。根据Markis分类，内脂素水平与孤立性CAE的严重程度之间存在显著相关性（r = -0.593，P < 0.001）。血浆内脂素水平可能反映孤立性CAE的存在和严重程度，提示内脂素可能参与孤立性CAE的发病机制。
