Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University and Seoul National University Dental Hospital, 101 Daehak-no, Jongno-gu, Seoul, 03080, Republic of Korea.
One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, Republic of Korea.
Sci Rep. 2024 Jan 2;14(1):163. doi: 10.1038/s41598-023-50370-3.
Majority of previous studies on alveolar ridge preservation (ARP) used collagen membranes as barrier membranes, and further evidence for ARP in dehiscent extraction sockets with a deproteinized bovine bone mineral (DBBM) and matrix is needed. The aim of this study is to assess the impact of non-cross linked collagen membranes (membrane) and crosslinked collagen matrices (matrix) on ARP using DBBM in extraction sockets with buccal dehiscence. In six mongrel dogs, the mesial roots of three mandibular premolars (P2, P3, and P4) were extracted 1 month after dehiscence defect induction. Two experimental groups were randomly assigned: (1) DBBM with a membrane (DBBM/membrane group) and (2) DBBM with a matrix (DBBM/matrix group). Three-dimensional (3D) volumetric, microcomputed tomography (μCT), and histologic analyses were performed to assess the ridge preservation. Both groups were effective to maintain the ridge width (p > 0.05), and the DBBM/matrix group showed more favorable soft tissue regeneration and bone quality in the histological analysis (p = 0.05). Based on these results, DBBM/matrix could be better choice for ARP in cases of buccal dehiscence defects.
大多数关于牙槽嵴保存（ARP）的先前研究都使用胶原膜作为屏障膜，并且需要进一步证明在有缺损的拔牙窝中使用去蛋白牛骨矿物质（DBBM）和基质的 ARP。本研究旨在评估非交联胶原膜（膜）和交联胶原基质（基质）对使用 DBBM 在颊侧缺损的拔牙窝中 ARP 的影响。在六只杂种犬中，在颊侧缺损诱导后 1 个月，拔除三个下颌前磨牙（P2、P3 和 P4）的近中根。将两组随机分配：（1）DBBM 加膜（DBBM/膜组）和（2）DBBM 加基质（DBBM/基质组）。进行三维（3D）体积、微计算机断层扫描（μCT）和组织学分析以评估嵴保存。两组均能有效维持嵴宽度（p>0.05），组织学分析显示 DBBM/基质组具有更好的软组织再生和骨质量（p=0.05）。基于这些结果，在颊侧缺损的情况下，DBBM/基质可能是 ARP 的更好选择。
