Department of Periodontology and Dental research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, Republic of Korea.
J Periodontol. 2021 Nov;92(11):1564-1575. doi: 10.1002/JPER.20-0832. Epub 2021 Feb 8.
The aim of this study was to evaluate the efficacy of deproteinized bovine bone mineral with 10% collagen (DBBM-C) soaked with hyaluronic acid (HA) for ridge preservation in compromised extraction sockets.
Bilateral third, fourth premolars and first molar were hemisected, distal roots were extracted, and then combined endodontic periodontal lesion was induced in the remaining mesial roots. After 4 months, the mesial roots were extracted and the following four treatments were randomly performed: Absorbable collagen sponge (ACS), ACS soaked with HA (ACS+HA), ridge preservation with DBBM-C covered with a collagen membrane (RP), ridge preservation with DBBM-C mixed with HA and covered with a collagen membrane (RP+HA). Animals were sacrificed at 1 and 3 months following treatment. Ridge dimensional changes and bone formation were examined using microcomputed tomography, histology, and histomorphometry.
At 1 month, ridge width was significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups, while the highest proportion of mineralized bone was observed in ACS+HA group. At 3 months, ridge width remained significantly higher in the RP and RP+HA groups than in the ACS and ACS+HA groups. ACS+HA and RP+HA treatments featured the highest proportion of mineralized bone and bone volume density compared with the other groups. No statistical difference was observed between ACS+HA and RP+HA treatments.
Ridge preservation with the mixture DBBM-C/HA prevented dimensional shrinkage and improved bone formation in compromised extraction sockets at 1 and 3 months.
本研究旨在评估脱蛋白牛骨矿物质与 10%胶原蛋白（DBBM-C）浸泡透明质酸（HA）用于保存受损拔牙窝牙槽嵴的疗效。
将双侧第三、四前磨牙和第一磨牙半切，远侧根拔除，然后在剩余的近侧根中诱导根管牙周联合病变。4 个月后，拔除近侧根，并随机进行以下四种处理：可吸收胶原海绵（ACS）、浸泡 HA 的 ACS（ACS+HA）、用胶原膜覆盖 DBBM-C 的牙槽嵴保存（RP）、与 HA 混合并用胶原膜覆盖 DBBM-C 的牙槽嵴保存（RP+HA）。处理后 1 个月和 3 个月处死动物。采用 microCT、组织学和组织形态计量学检查牙槽嵴的尺寸变化和骨形成。
在 1 个月时，RP 和 RP+HA 组的牙槽嵴宽度明显高于 ACS 和 ACS+HA 组，而 ACS+HA 组的矿化骨比例最高。在 3 个月时，RP 和 RP+HA 组的牙槽嵴宽度仍明显高于 ACS 和 ACS+HA 组。ACS+HA 和 RP+HA 处理组的矿化骨和骨体积密度比例明显高于其他组。ACS+HA 和 RP+HA 处理组之间无统计学差异。
DBBM-C/HA 混合物的牙槽嵴保存可防止 1 个月和 3 个月时受损拔牙窝牙槽嵴的尺寸收缩，并促进骨形成。
