Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, PR China.
Department of Pathophysiology, College of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, PR China.
Cell Commun Signal. 2024 Jan 2;22(1):11. doi: 10.1186/s12964-023-01445-1.
Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproduction, embryonic development, fibrogenesis and tumorigenesis through polyamine and other signaling pathways. Dysregulation of AZINs has involved in multiple human diseases, especially malignant tumors. Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans. Additionally, the high frequencies of RNA-edited AZIN1 in human cancers correlates with increase of cancer cell proliferation, enhancement of cancer cell stemness, and promotion of tumor angiogenesis. In this review, we summarize the current knowledge on the various contribution of AZINs related with potential cancer promotion, cancer stemness, microenvironment and RNA modification, especially underlying molecular mechanisms, and furthermore explored its promising implication for cancer diagnosis and treatment.
多胺代谢对生理过程至关重要。鸟氨酸脱羧酶（ODC）抗酶抑制剂（AZINs）能够与抗酶（AZs）相互作用，从而将 ODC 从 ODC-AZs 复合物中释放出来，并促进多胺的生物合成。AZINs 通过多胺和其他信号通路调节生殖、胚胎发育、纤维化和肿瘤发生。AZINs 的失调涉及多种人类疾病，特别是恶性肿瘤。腺苷到肌苷（A-to-I）RNA 编辑是人类最常见的转录后核苷酸修饰类型。此外，人类癌症中高频率的 RNA 编辑的 AZIN1 与癌细胞增殖增加、癌细胞干性增强和肿瘤血管生成促进相关。在这篇综述中，我们总结了 AZINs 在促进癌症、癌症干性、微环境和 RNA 修饰方面的各种潜在作用的最新知识，特别是其潜在的分子机制，并进一步探讨了其在癌症诊断和治疗方面的应用前景。
