Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
PLoS One. 2024 Jan 3;19(1):e0294567. doi: 10.1371/journal.pone.0294567. eCollection 2024.
Lower testosterone levels in men have been consistently associated with metabolic abnormalities, particularly obesity. This study aims to investigate the relationship between testosterone and obesity by analyzing the correlation between testosterone levels and body fat percentage using data from the NHANES (National Health and Nutrition Examination Survey) database.
The study included a total of 5959 participants from the NHANES 2011-2016. Multivariable linear regression models were used to assess the association between testosterone levels and body composition parameters, including total percent fat (TPF), android percent fat (APF), gynoid percent fat (GPF), android to gynoid ratio (A/G), and lean mass percent (LMP). Subgroup analyses stratified by sex were conducted using multivariable linear regression. To account for potential non-linear relationships, fitted smoothing curves and generalized additive models were utilized. A separate analysis of participants with a BMI ≥ 30 kg/m2 was conducted to validate the conclusions.
Among males, testosterone levels showed a significant negative correlation with TPF (β = -11.97, P <0.0001), APF (β = -9.36, P<0.0001), GPF (β = -10.29, P <0.0001), and A/G (β = -320.93, P<0.0001), while a positive correlation was observed between LMP and testosterone levels (β = 12.62, P<0.0001). In females, a contrasting pattern emerged in the relationship between testosterone and body fat, but no significant correlation was found between testosterone and body composition in obese women.
The findings of this study support a negative association between body fat and testosterone levels in males.
男性的睾丸激素水平与代谢异常，尤其是肥胖密切相关。本研究旨在通过分析 NHANES（国家健康和营养检查调查）数据库中睾丸激素水平与体脂百分比之间的相关性，研究睾丸激素与肥胖之间的关系。
本研究共纳入了 NHANES 2011-2016 年的 5959 名参与者。使用多变量线性回归模型评估了睾丸激素水平与身体成分参数（总脂肪百分比[TPF]、安卓脂肪百分比[APF]、臀肌脂肪百分比[GPF]、安卓到臀肌比例[A/G]和瘦体重百分比[LMP]）之间的相关性。采用多变量线性回归对性别分层的亚组进行了分析。为了考虑潜在的非线性关系，使用了拟合平滑曲线和广义加性模型。对 BMI≥30kg/m2 的参与者进行了单独的分析，以验证结论的可靠性。
在男性中，睾丸激素水平与 TPF（β=-11.97，P<0.0001）、APF（β=-9.36，P<0.0001）、GPF（β=-10.29，P<0.0001）和 A/G（β=-320.93，P<0.0001）呈显著负相关，而与 LMP 呈正相关（β=12.62，P<0.0001）。在女性中，睾丸激素与体脂之间的关系呈现出相反的模式，但在肥胖女性中，睾丸激素与身体成分之间没有显著相关性。
本研究的结果支持男性体脂与睾丸激素水平之间存在负相关关系。
