Brisson Emma R L, Worthington Max J H, Kerai Simran, Müllner Markus
Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney 2006 NSW, Australia.
The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Sydney 2006 NSW, Australia.
Chem Soc Rev. 2024 Feb 19;53(4):1984-2021. doi: 10.1039/d1cs01114f.
Polymer self-assembly has become a reliable and versatile workhorse to produce polymeric nanomaterials. With appropriate polymer design and monomer selection, polymers can assemble into shapes and morphologies beyond well-studied spherical and cylindrical micellar structures. Steadfast access to anisotropic polymer nanoparticles has meant that the fabrication and application of 2D soft matter has received increasing attention in recent years. In this review, we focus on nanoscale polymer discs, toroids, and platelets: three morphologies that are often interrelated and made from similar starting materials or common intermediates. For each morphology, we illustrate design rules, and group and discuss commonly used self-assembly strategies. We further highlight polymer compositions, fundamental principles and self-assembly conditions that enable precision in bottom-up fabrication strategies. Finally, we summarise potential applications of such nanomaterials, especially in the context of biomedical research and template chemistry and elaborate on future endeavours in this space.
聚合物自组装已成为制备聚合物纳米材料的一种可靠且通用的方法。通过适当的聚合物设计和单体选择,聚合物可以组装成除了研究充分的球形和圆柱形胶束结构之外的形状和形态。能够稳定地获得各向异性聚合物纳米颗粒意味着二维软物质的制备和应用近年来受到了越来越多的关注。在本综述中,我们聚焦于纳米级聚合物圆盘、环面和片晶:这三种形态通常相互关联,且由相似的起始材料或常见中间体制成。对于每种形态,我们阐述设计规则,并对常用的自组装策略进行分类和讨论。我们进一步强调能够在自下而上的制备策略中实现精确性的聚合物组成、基本原理和自组装条件。最后,我们总结此类纳米材料的潜在应用,特别是在生物医学研究和模板化学背景下的应用,并详细说明该领域未来的努力方向。