Azimi Seyed Mahmoud, Mohammadian Baharak, Khezri Mohammad
Foot and Mouth Disease Reference Laboratory, Razi Vaccine and Serum Research Institute, Agricultural research, Education and Extension Organization (AREEO), Karaj, Iran.
Department of Honey Bee, Silk worm and Wildlife Research, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran.
Vet Res Forum. 2023;14(12):681-684. doi: 10.30466/vrf.2023.1990250.3794. Epub 2023 Dec 15.
Foot-and-mouth disease (FMD), a highly contagious viral disease of livestock, is endemic in Iran. To investigate the prevalence of antibodies against 3ABC non-structural protein (NSP) of FMD virus, a cross-sectional study was conducted on dairy cattle in eight cities of Kurdistan Province from May to September 2016. Serum samples (n = 283), were collected from cattle vaccinated with the recommended dose of a commercial vaccine and tested by a Competition enzyme-linked immunosorbent assay. Results showed the overall seroprevalence of antibodies against NSP of FMD virus in the vaccinated cattle was 22.30% (95.00% CI: 17.40 - 27.20%). The seroprevalence of antibodies was affected by geographical regions, with the highest seroprevalence related to the samples of vaccinated cattle in the cities of Marivan 95.00% (95.00% CI: 92.50 - 97.50%) and Saqqez 38.50% (95.00% CI: 32.80 - 44.20%). In terms of age, the highest seroprevalence of antibodies to FMD virus 26.70% (95.00% CI: 21.60-31.80%) belonged to ≤ 24-month-old cattle. These findings suggest that the presence of NSP antibodies in vaccinated cattle indicates the risk of infection with FMD virus serotypes circulating in the west of the province, so further studies with a larger sample size are recommended.
口蹄疫（FMD）是一种高度传染性的家畜病毒性疾病，在伊朗呈地方性流行。为调查口蹄疫病毒3ABC非结构蛋白（NSP）抗体的流行情况，于2016年5月至9月在库尔德斯坦省八个城市的奶牛中开展了一项横断面研究。从接种了推荐剂量商业疫苗的奶牛中采集血清样本（n = 283），并通过竞争酶联免疫吸附试验进行检测。结果显示，接种疫苗的奶牛中口蹄疫病毒NSP抗体的总体血清阳性率为22.30%（95.00%CI：17.40 - 27.20%）。抗体血清阳性率受地理区域影响，血清阳性率最高的是马里万市接种疫苗奶牛的样本，为95.00%（95.00%CI：92.50 - 97.50%），萨盖兹市为38.50%（95.00%CI：32.80 - 44.20%）。在年龄方面，口蹄疫病毒抗体血清阳性率最高的是≤24月龄的奶牛，为26.70%（95.00%CI：21.60 - 31.80%）。这些发现表明，接种疫苗的奶牛中存在NSP抗体表明该省西部存在口蹄疫病毒血清型感染风险，因此建议进行更大样本量的进一步研究。
