Klinik Für Innere Medizin II, Hämatologie Und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Klinik Für HNO-Erkrankungen, Südharz-Klinikum Nordhausen, Dr.-Robert-Koch-Str. 39, 99734, Nordhausen, Germany.
Eur Arch Otorhinolaryngol. 2024 May;281(5):2195-2209. doi: 10.1007/s00405-023-08375-1. Epub 2024 Jan 4.
In this systematic review, we included randomized controlled trials from 2004 to 2021 to determine the effect of individual dietary counseling for patients with head and neck cancer, specifically, nutritional outcome, morbidity, and quality of life (QOL), during and after chemo- and chemoradiotherapy.
In October 2023, a systematic search was conducted searching five electronic databases (Embase, Cochrane, PsychInfo, CINAHL, and Medline) to find studies concerning the use and effectiveness of intensive nutritional care on head and neck cancer patients.
From all 2565 search results, 6 studies with 685 head and neck cancer patients were included in this systematic review. The patients were treated with radiotherapy or radiochemotherapy. The therapy concepts include intensive nutritional support from a dietician. Outcomes were nutritional status, body composition, quality of life, and adverse effect. All studies had low quality, high risk of bias, and reported heterogeneous results: some studies reported significant improved nutrition status, body composition and quality of life, while other studies did not find any changes concerning these endpoints.
Due to the very heterogeneous results and methodical limitations of the included studies, a clear statement regarding the effectiveness of intensive nutritional therapy of head and neck cancer patients is not possible. Further well-planned studies are needed.
在这项系统评价中,我们纳入了 2004 年至 2021 年的随机对照试验,以确定针对头颈部癌症患者的个体化饮食咨询的效果,具体而言,包括在放化疗和放化疗期间和之后的营养结局、发病率和生活质量(QOL)。
在 2023 年 10 月,我们进行了系统检索,在五个电子数据库(Embase、Cochrane、PsychInfo、CINAHL 和 Medline)中搜索有关密集营养护理对头颈部癌症患者的使用和有效性的研究。
从所有 2565 项搜索结果中,我们纳入了这项系统评价中的 6 项研究,共 685 名头颈部癌症患者。患者接受放疗或放化疗治疗。治疗方案包括营养师提供的密集营养支持。结局包括营养状况、身体成分、生活质量和不良反应。所有研究的质量均较低,存在高偏倚风险,报告的结果存在异质性:一些研究报告了营养状况、身体成分和生活质量的显著改善,而其他研究则未发现这些终点有任何变化。
由于纳入研究的结果非常异质且存在方法学局限性,因此无法对头颈部癌症患者的密集营养治疗的有效性做出明确的陈述。需要进一步进行精心设计的研究。