Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, TX, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, TX, USA; Garrison Institute on Aging, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, TX, USA.
Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, TX, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center (TTUHSC), Lubbock, TX, USA.
Neuron. 2024 Jan 3;112(1):1-3. doi: 10.1016/j.neuron.2023.12.006.
Negative affective aspects of alcohol withdrawal and pain involve converging brain circuits. In this issue of Neuron, Son et al. identify a peripheral mechanism of an alcohol-withdrawal-induced headache-like condition, which is centered on mast-cell-specific receptor MrgprB2 activated by corticotropin-releasing factor (CRF) in dura mater to drive nociception.
酒精戒断和疼痛的负面情绪方面涉及到趋同的大脑回路。在本期《神经元》杂志上，Son 等人确定了一种酒精戒断引起的头痛样病症的外周机制，该机制以位于硬脑膜中的肥大细胞特异性受体 MrgprB2 为中心，该受体受促肾上腺皮质释放因子 (CRF)激活，从而驱动伤害感受。
