College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China.
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
Int J Biol Macromol. 2024 Feb;259(Pt 1):129124. doi: 10.1016/j.ijbiomac.2023.129124. Epub 2024 Jan 3.
The wound of diabetes has long-term excessive inflammation leading to wound fibrosis and scar formation. In the process of diabetic wound healing, good wound dressing is required for intervention. In this study, we designed a dihydromyricetin-loaded hydrogel (PCD) based on phellinus igniarius polysaccharide and l-arginine modified chitosan as an alternative material to promote diabetes wound healing. PCD had a uniform porous structure, good thermal stability, excellent mechanical properties, high water absorption, excellent antioxidant and anti-inflammatory activities and good biocompatibility and biodegradability. In addition, in the full-thickness skin trauma model of diabetes, PCD significantly inhibited the JNK signaling pathway to reduce inflammatory response, and significantly down-regulated the expression of TGF-β1, Smad2, Smad3 and Smad4 to directly inhibit the TGF-β/Smad signaling pathway to accelerate wound healing and slow down scar formation in diabetes mice. Therefore, PCD has a broad application prospect in promoting diabetes wound healing.
糖尿病伤口长期存在过度炎症，导致伤口纤维化和瘢痕形成。在糖尿病伤口愈合过程中，需要良好的伤口敷料进行干预。在本研究中，我们设计了一种以桑黄多糖和 l-精氨酸修饰壳聚糖为基础的二氢杨梅素水凝胶（PCD）作为替代材料，以促进糖尿病伤口愈合。PCD 具有均匀的多孔结构、良好的热稳定性、优异的机械性能、高吸水性、出色的抗氧化和抗炎活性以及良好的生物相容性和可生物降解性。此外，在糖尿病全层皮肤创伤模型中，PCD 显著抑制 JNK 信号通路以减少炎症反应，并显著下调 TGF-β1、Smad2、Smad3 和 Smad4 的表达，直接抑制 TGF-β/Smad 信号通路，从而加速糖尿病小鼠的伤口愈合并减缓瘢痕形成。因此，PCD 在促进糖尿病伤口愈合方面具有广阔的应用前景。
