Department of Gastroenterology, The 960th Hospital of the PLA, 250000 Jinan, Shandong, China.
Liver Research Unit, Medica Sur Clinic & Foundation and Faculty of Medicine, National Autonomous University of Mexico, 14050 Mexico City, Mexico.
Front Biosci (Landmark Ed). 2023 Dec 28;28(12):359. doi: 10.31083/j.fbl2812359.
Stem cell therapy offers a promising avenue for advanced liver disease cases as an alternative to liver transplantation. Clinical studies are underway to explore the potential of stem cells from various sources in treating different liver diseases. However, due to the variability among current studies, further validation is needed to ensure the safety and effectiveness of stem cell therapy. To establish a strong foundation for optimal stem cell therapy applications, selection of suitable stem cell sources, standardization of transplantation protocols, and patient criteria are vital. This review comprehensively examines existing literature on stem cell sources, transplantation methods, and patient selection. Additionally, we discuss novel strategies, including stem cell preconditioning, cell-free therapy, genetic modification of stem cells, and the use of liver organoids, addressing the limitations of current stem cell therapies. Nevertheless, these innovative approaches require further validation.
干细胞治疗为晚期肝病病例提供了一种有前途的治疗方法，可作为肝移植的替代方案。目前正在进行临床研究，以探索来自不同来源的干细胞在治疗不同类型肝脏疾病中的潜力。然而，由于目前研究的变异性，需要进一步验证以确保干细胞治疗的安全性和有效性。为了为最佳干细胞治疗应用奠定坚实基础，选择合适的干细胞来源、移植方案标准化和患者标准至关重要。本综述全面考察了关于干细胞来源、移植方法和患者选择的现有文献。此外，我们还讨论了一些新策略，包括干细胞预处理、无细胞治疗、干细胞遗传修饰和使用肝类器官，以解决当前干细胞治疗的局限性。然而，这些创新方法需要进一步验证。
