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三维类器官研究对再生医学中干细胞治疗的启示。

Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine.

机构信息

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.

出版信息

Stem Cell Rev Rep. 2024 Feb;20(2):509-523. doi: 10.1007/s12015-023-10655-6. Epub 2023 Dec 14.

DOI:10.1007/s12015-023-10655-6
PMID:38095787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10837234/
Abstract

Regenerative medicine has developed as a promising discipline that utilizes stem cells to address limitations in traditional therapies, using innovative techniques to restore and repair damaged organs and tissues. One such technique is the generation of three-dimensional (3D) organoids in stem cell therapy. Organoids are 3D constructs that resemble specific organs' structural and functional characteristics and are generated from stem cells or tissue-specific progenitor cells. The use of 3D organoids is advantageous in comparison to traditional two-dimensional (2D) cell culture by bridging the gap between in vivo and in vitro research. This review aims to provide an overview of the advancements made towards regenerative medicine using stem cells to generate organoids, explore the techniques used in generating 3D organoids and their applications and finally elucidate the challenges and future directions in regenerative medicine using 3D organoids.

摘要

再生医学作为一门有前途的学科得到了发展，它利用干细胞利用创新技术来解决传统疗法的局限性，从而恢复和修复受损的器官和组织。干细胞治疗中生成三维（3D）类器官就是一种这样的技术。类器官是一种 3D 结构，具有特定器官的结构和功能特征，并由干细胞或组织特异性祖细胞生成。与传统的二维（2D）细胞培养相比，3D 类器官的使用具有优势，因为它弥补了体内和体外研究之间的差距。本综述旨在概述使用干细胞生成类器官的再生医学进展，探讨生成 3D 类器官的技术及其应用，并最终阐明使用 3D 类器官进行再生医学的挑战和未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/ba797e554943/12015_2023_10655_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/0b67fb450af1/12015_2023_10655_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/3a55ce01a89e/12015_2023_10655_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/9a97133020e4/12015_2023_10655_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/ba797e554943/12015_2023_10655_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/0b67fb450af1/12015_2023_10655_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/3a55ce01a89e/12015_2023_10655_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/9a97133020e4/12015_2023_10655_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2d/10837234/ba797e554943/12015_2023_10655_Fig4_HTML.jpg

相似文献

[1]
Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine.

Stem Cell Rev Rep. 2024-2

[2]
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[3]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Veterinary Regenerative Medicine: The Evolving Role of Stem Cell-Based Therapies.

Stem Cell Rev Rep. 2025-9-3

[2]
The modeling of human implantation and early placentation: achievements and perspectives.

Hum Reprod Update. 2025-3-1

[3]
ESOT Roadmap for Advanced Therapy Medicinal Products in Transplantation: Navigating Regulatory Challenges to Enhance Access and Care.

Transpl Int. 2024

[4]
An Overview of Multiple Sclerosis In Vitro Models.

Int J Mol Sci. 2024-7-16

[5]
Growing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases.

Cells. 2024-6-18

本文引用的文献

[1]
Stem cells for organoids.

Smart Med. 2022-12-27

[2]
Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.

Biophys Rev (Melville). 2021-6-17

[3]
Enhancing generation efficiency of liver organoids in a collagen scaffold using human chemically derived hepatic progenitors.

Ann Hepatobiliary Pancreat Surg. 2023-11-30

[4]
Melatonin blunted the angiogenic activity in 3D colon cancer tumoroids by the reduction of endocan.

Cancer Cell Int. 2023-6-19

[5]
Organoids.

Nat Rev Methods Primers. 2022

[6]
Organoids: The current status and biomedical applications.

MedComm (2020). 2023-5-17

[7]
Small molecule metabolites: discovery of biomarkers and therapeutic targets.

Signal Transduct Target Ther. 2023-3-20

[8]
Organoid-based 3D in vitro microphysiological systems as alternatives to animal experimentation for preclinical and clinical research.

Arch Toxicol. 2023-5

[9]
Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases.

Int J Mol Sci. 2023-2-16

[10]
Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review.

ADMET DMPK. 2022-10-10

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