Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Mol Cell. 2024 Jan 4;84(1):120-130. doi: 10.1016/j.molcel.2023.12.005.
To survive, all organisms need the ability to accurately recognize and neutralize pathogens. As a result, many of the fundamental strategies that our innate immune system uses to fight infection have deep evolutionary roots. The innate immune sensor cyclic-GMP-AMP synthase (cGAS), an enzyme that plays a critical role in our bodies by sensing and signaling in response to microbial infection, is broadly conserved and has functional homologs in many vertebrates, invertebrates, and even bacteria. In this review, we will provide an overview of cGAS and cGAS-like signaling in eukaryotes before discussing cGAS-like homologs in bacteria.
为了生存，所有生物都需要能够准确识别和中和病原体的能力。因此，我们的先天免疫系统用来对抗感染的许多基本策略都有很深的进化根源。先天免疫传感器环鸟苷酸-腺苷酸合酶（cGAS）是一种在我们的身体中起着至关重要的作用的酶，它通过感应和信号转导来感知微生物感染，在许多脊椎动物、无脊椎动物甚至细菌中都广泛保守，并具有功能同源物。在讨论细菌中的 cGAS 样同源物之前，我们将对真核生物中的 cGAS 和 cGAS 样信号转导进行概述。
