快照：DNA 修复途径。

SnapShot: DNA repair pathways.

机构信息

IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy.

IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia, Italy.

出版信息

Mol Cell. 2024 Jan 4;84(1):180-180.e1. doi: 10.1016/j.molcel.2023.11.030.

DOI:10.1016/j.molcel.2023.11.030

PMID:38181759

Abstract

The genetic information stored in DNA is under continuous threat by endogenous and environmental sources of DNA damage. Cells have evolved multiple DNA repair pathways that function in overlapping manners, with principles shared across species. Here, we depict the main DNA repair pathways cells rely on, with the primary lesions they are tackling, along with key players and main DNA transactions. To view this SnapShot, open or download the PDF.

摘要

存储在 DNA 中的遗传信息持续受到内源性和环境性 DNA 损伤源的威胁。细胞已经进化出多种以重叠方式发挥作用的 DNA 修复途径，这些途径在物种间具有共同的原则。在这里，我们描述了细胞依赖的主要 DNA 修复途径，以及它们正在解决的主要损伤，以及关键参与者和主要的 DNA 交易。要查看此 SnapShot，请打开或下载 PDF。