Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Gwalior, Madhya Pradesh 4774005, India.
Department of Pharmaceutics, ShriRam college of Pharmacy, Banmore 476444, India.
Int J Biol Macromol. 2024 Feb;259(Pt 1):129131. doi: 10.1016/j.ijbiomac.2023.129131. Epub 2024 Jan 3.
In recent years, inulin has gained much attention as a promising multifunctional natural biopolymer with numerous applications in drug delivery, prebiotics, and therapeutics. It reveals a multifaceted biopolymer with transformative implications by elucidating the intricate interplay between inulin and the host, microbiome, and therapeutic agents. Their flexible structure, exceptional targetability, biocompatibility, inherent ability to control release behavior, tunable degradation kinetics, and protective ability make them outstanding carriers in healthcare and biomedicine. USFDA has approved Inulin as a nutritional dietary supplement for infants. The possible applications of inulin in biomedicine research inspired by nature are presented. The therapeutic potential of inulin goes beyond its role in prebiotics and drug delivery. Recently, significant research efforts have been made towards inulin's anti-inflammatory, antioxidant, and immunomodulatory properties for their potential applications in treating various chronic diseases. Moreover, its ability to reduce inflammation and modulate immune responses opens new avenues for treating conditions such as autoimmune disorders and gastrointestinal ailments. This review will attempt to illustrate the inulin's numerous and interconnected roles, shedding light on its critical contributions to the advancement of healthcare and biomedicine and its recent advancement in therapeutics, and conclude by taking valuable insights into the prospects and opportunities of inulin.
近年来,菊粉作为一种很有前途的多功能天然生物聚合物,在药物传递、益生元和治疗学等方面有诸多应用,受到了广泛关注。它揭示了菊粉与宿主、微生物组和治疗剂之间错综复杂的相互作用,是一种具有多方面功能的生物聚合物,具有变革性的意义。其灵活的结构、卓越的靶向性、生物相容性、固有控制释放行为的能力、可调节的降解动力学和保护能力,使它们成为医疗保健和生物医学领域的杰出载体。美国食品和药物管理局已批准菊粉作为婴儿营养膳食补充剂。本文介绍了受自然启发的菊粉在生物医学研究中的可能应用。菊粉的治疗潜力超出了其在益生元和药物传递方面的作用。最近,人们对菊粉的抗炎、抗氧化和免疫调节特性进行了大量研究,以期将其应用于治疗各种慢性疾病。此外,它减轻炎症和调节免疫反应的能力为治疗自身免疫性疾病和胃肠道疾病等疾病开辟了新的途径。本文将尝试说明菊粉的众多相互关联的作用,阐明其对医疗保健和生物医学发展的重要贡献,以及其在治疗学方面的最新进展,并通过深入了解菊粉的前景和机遇,得出结论。