School of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China.
Kailuan General Hospital, Tangshan, People's Republic of China.
J Endocrinol Invest. 2024 Jul;47(7):1657-1665. doi: 10.1007/s40618-023-02279-x. Epub 2024 Jan 6.
Remnant cholesterol (RC) is a contributor to cardiovascular diseases, obesity, diabetes, and metabolic syndrome. However, the specific relationship between RC and bone metabolism remains unexplored. Therefore, we aimed to investigate the relationships of RC with hip bone mineral density (BMD) and the risk of low bone mass.
Physical examination data was collected from men aged < 60 years as part of the Kailuan Study between 2014 and 2018. The characteristics of the participants were compared between RC quartile groups. A generalized linear regression model was used to evaluate the relationship between RC and hip BMD and a logistic regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for low bone mass. Additional analyses were performed after stratification by body mass index (BMI) (≥ or < 24 kg/m). Sensitivity analyses were performed by excluding individuals who were taking lipid-lowering therapy or had cancer, cardiovascular diseases, or diabetes.
Data from a total of 7,053 participants were included in the analysis. After adjustment for confounding factors, RC negatively correlated with hip BMD (β = - 0.0079, 95% CI: - 0.0133, - 0.0025). The risk of low bone mass increased from the lowest to the highest RC quartile, with ORs of 1 (reference), 1.09 (95% CI: (0.82, 1.44), 1.35 (95%CI: 1.02, 1.77), and 1.43 (95% CI: 1.09, 1.89) for Q1, Q2, Q3, and Q4, respectively (P for trend = 0.004) in the fully adjusted model. Compared to RC < 0.80 mmol/l group, the risk of low bone mass increased 39% in RC ≥ 0.80 mmol/l group (P < 0.001). The correlation between RC and hip BMD was stronger in participants with BMI ≥ 24 kg/m group (β = - 0.0159, 95% CI: - 0.0289, - 0.0029). The results of sensitivity analyses were consistent with the main results.
We have identified a negative correlation between serum RC and hip BMD, and a higher RC concentration was found to be associated with a greater risk of low bone mass in young and middle-aged men.
残余胆固醇（RC）是心血管疾病、肥胖症、糖尿病和代谢综合征的致病因素之一。然而，RC 与骨代谢之间的具体关系仍未被探索。因此，我们旨在研究 RC 与髋部骨密度（BMD）和低骨量风险之间的关系。
2014 年至 2018 年期间，作为开滦研究的一部分，对年龄<60 岁的男性进行了体格检查数据收集。比较了 RC 四分位组参与者的特征。采用广义线性回归模型评估 RC 与髋部 BMD 的关系，采用 logistic 回归模型计算低骨量的比值比（OR）和 95%置信区间（CI）。按体重指数（BMI）（≥或<24kg/m）进行分层后进行了额外分析。排除服用降脂药物或患有癌症、心血管疾病或糖尿病的个体后进行了敏感性分析。
共有 7053 名参与者的数据纳入分析。在调整混杂因素后，RC 与髋部 BMD 呈负相关（β= -0.0079，95%CI：-0.0133，-0.0025）。低骨量风险从 RC 最低四分位组到最高四分位组逐渐升高，OR 值分别为 1（参考）、1.09（95%CI：0.82，1.44）、1.35（95%CI：1.02，1.77）和 1.43（95%CI：1.09，1.89），Q1、Q2、Q3 和 Q4 组的趋势检验 P 值=0.004。与 RC<0.80mmol/l 组相比，RC≥0.80mmol/l 组低骨量风险增加 39%（P<0.001）。RC 与髋部 BMD 之间的相关性在 BMI≥24kg/m 组更强（β= -0.0159，95%CI：-0.0289，-0.0029）。敏感性分析的结果与主要结果一致。
我们发现血清 RC 与髋部 BMD 呈负相关，较高的 RC 浓度与年轻和中年男性低骨量风险增加相关。
