Diribe Onyinye, Palmer Karen, Kennedy Adee, Betts Marissa, Borkowska Katarzyna, Dessapt-Baradez Cecile, Baxter Mike
Sanofi UK, 410 Thames Valley Park Drive, Reading, RG6 1PT, UK.
Sanofi US, 55 Corporate Drive, Bridgewater, NJ, 08807, USA.
Diabetes Ther. 2024 Feb;15(2):367-380. doi: 10.1007/s13300-023-01513-2. Epub 2024 Jan 6.
The psychological burden of type 1 diabetes mellitus (T1DM) is considerable. The condition affects the daily lives of adults living with T1DM (ALWT1DM) in many ways. International guidelines highlight the importance of providing psychological support to ALWT1DM to improve health outcomes and well-being.
We conducted a systematic literature review of randomised controlled trials (RCTs) to identify the evidence on the impact of psychological interventions on glycaemic control and psychological outcomes in ALWT1DM. Literature searches of Medline, Embase, Cochrane Central Register of Controlled Trials, PsycInfo, and the grey literature were performed to identify relevant RCTs, published in English, from 2001 onward. Fourteen RCTs of ten psychological interventions in ALWT1DM were eligible and included in the qualitative synthesis. The studies varied considerably in terms of duration, target population, endpoints, and efficacy.
Overall, psychological interventions did not perform significantly better than control treatments in improving glycaemic control, although selected patient groups did report benefits from some psychological intervention types, such as cognitive behavioural therapy. Although most of the psychological interventions produced small, nonsignificant improvements in self-reported patient functioning, some treatments were effective in reducing diabetes distress and improving mental health, even if no impact on glycaemic control was observed.
Current guidelines for the treatment of T1DM recommend access to psychological services; however, there is a paucity of high-quality evidence from clinical trials on the effectiveness or preferred structure of psychological support. There is a clear need for more rigorous, large-scale, international research to address the efficacy of psychological interventions in ALWT1DM.
1型糖尿病(T1DM)带来的心理负担相当大。这种疾病在许多方面影响着成年1型糖尿病患者(ALWT1DM)的日常生活。国际指南强调了为ALWT1DM提供心理支持以改善健康结果和幸福感的重要性。
我们对随机对照试验(RCT)进行了系统的文献综述,以确定心理干预对ALWT1DM血糖控制和心理结果影响的证据。检索了Medline、Embase、Cochrane对照试验中央注册库、PsycInfo以及灰色文献,以识别2001年以后发表的英文相关RCT。14项针对ALWT1DM的10种心理干预的RCT符合条件并纳入定性综合分析。这些研究在持续时间、目标人群、终点和疗效方面差异很大。
总体而言,在改善血糖控制方面,心理干预并不比对照治疗有显著更好的效果,尽管部分患者群体确实报告从某些心理干预类型中受益,如认知行为疗法。虽然大多数心理干预在患者自我报告的功能方面产生了微小的、不显著的改善,但一些治疗在减轻糖尿病困扰和改善心理健康方面是有效的,即使未观察到对血糖控制有影响。
目前T1DM的治疗指南建议提供心理服务;然而,关于心理支持的有效性或首选结构,临床试验中高质量证据匮乏。显然需要更严格、大规模的国际研究来探讨心理干预对ALWT1DM的疗效。