高剂量和低剂量体外冲击波疗法对老年骨关节炎患者免疫激活及免疫抑制标志物的影响：一项随机对照试验的研究方案
The effects of high and low dose extracorporeal shockwave therapy on immune activation and immunosuppressive markers in elderly patients with osteoarthritis: a study protocol for a randomized controlled trial.
作者信息
Sheng Yilan, Yuan Haiyin, Chen Lihua, Yu Bo
机构信息
Department of Rehabilitation, Shanghai Fifth Rehabilitation Hospital No. 279, Ledu Road, Shanghai 201600, China.
Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiaotong University No. 100, Haining Road, Shanghai 200080, China.
出版信息
Am J Clin Exp Immunol. 2023 Dec 15;12(6):164-172. eCollection 2023.
OBJECTIVE
This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.
METHODS
120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/) or low dose (0.10 mJ/) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.
RESULTS
High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.
CONCLUSION
This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.
目的
本随机对照试验旨在比较高剂量与低剂量体外冲击波疗法（ESWT）对老年骨关节炎患者免疫系统激活和调节的影响。
方法
120例65岁及以上的膝骨关节炎患者将被随机分配，分别接受高剂量（0.25 mJ/）或低剂量（0.10 mJ/）的ESWT治疗，每周一次，共4周。在基线、干预后4周和1个月随访时测量血清细胞因子、刺激的免疫细胞亚群和T调节细胞。
结果
在老年骨关节炎患者中，高剂量ESWT与低剂量ESWT相比，可能主要导致促炎细胞因子增加和免疫抑制性T调节细胞减少。
结论
本研究将为ESWT给药方案及其不同的免疫调节作用提供证据，可为老年人群肌肉骨骼疾病的最佳治疗提供指导。
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