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本文引用的文献

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The Impact of T-cell Aging on Alloimmunity and Inflammaging.T 细胞衰老对同种异体免疫和炎症老化的影响。
Transplantation. 2024 Mar 1;108(3):634-642. doi: 10.1097/TP.0000000000004715. Epub 2023 Jun 30.
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HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways.HK2：通过糖酵解和非糖酵解途径调控骨关节炎的潜在因子。
Cell Commun Signal. 2022 Aug 30;20(1):132. doi: 10.1186/s12964-022-00943-y.
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HERVs Role in the Pathogenesis, Diagnosis or Prognosis of Aging Diseases: A Systematic Review.HERVs 在衰老相关疾病的发病机制、诊断或预后中的作用：系统评价。
Curr Mol Med. 2023 May 30;23(7):678-687. doi: 10.2174/1566524022666220525144135.
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2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis.2022 年美国风湿病学会/欧洲风湿病学会联合会嗜酸性肉芽肿伴多血管炎分类标准。
Ann Rheum Dis. 2022 Mar;81(3):309-314. doi: 10.1136/annrheumdis-2021-221794. Epub 2022 Feb 2.
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Extracorporeal Shockwave Therapy in the Management of Sports Medicine Injuries.体外冲击波疗法在运动医学损伤治疗中的应用。
Curr Sports Med Rep. 2021 Jun 1;20(6):298-305. doi: 10.1249/JSR.0000000000000851.
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Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases.Treg 细胞发育和功能的转录和表观遗传学基础：自身免疫性疾病中的遗传异常或变异。
Cell Res. 2020 Jun;30(6):465-474. doi: 10.1038/s41422-020-0324-7. Epub 2020 May 4.
7
The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: A systematic review and meta-analysis.体外冲击波疗法治疗膝骨关节炎的疗效和安全性：系统评价和荟萃分析。
Int J Surg. 2020 Mar;75:24-34. doi: 10.1016/j.ijsu.2020.01.017. Epub 2020 Jan 21.
8
OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis.OARSI 骨关节炎治疗指南：膝关节、髋关节和多关节骨关节炎的非手术治疗。
Osteoarthritis Cartilage. 2019 Nov;27(11):1578-1589. doi: 10.1016/j.joca.2019.06.011. Epub 2019 Jul 3.
9
Measurement Properties of Visual Analogue Scale, Numeric Rating Scale, and Pain Severity Subscale of the Brief Pain Inventory in Patients With Low Back Pain: A Systematic Review.用于评估腰痛患者疼痛程度的视觉模拟评分法、数字评分法和简明疼痛量表疼痛严重程度子量表的测量特性：系统评价。
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Ageing and the pathogenesis of osteoarthritis.衰老与骨关节炎的发病机制
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高剂量和低剂量体外冲击波疗法对老年骨关节炎患者免疫激活及免疫抑制标志物的影响：一项随机对照试验的研究方案

The effects of high and low dose extracorporeal shockwave therapy on immune activation and immunosuppressive markers in elderly patients with osteoarthritis: a study protocol for a randomized controlled trial.

作者信息

Sheng Yilan, Yuan Haiyin, Chen Lihua, Yu Bo

机构信息

Department of Rehabilitation, Shanghai Fifth Rehabilitation Hospital No. 279, Ledu Road, Shanghai 201600, China.

Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiaotong University No. 100, Haining Road, Shanghai 200080, China.

出版信息

Am J Clin Exp Immunol. 2023 Dec 15;12(6):164-172. eCollection 2023.

PMID:38187367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10767198/
Abstract

OBJECTIVE

This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.

METHODS

120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/) or low dose (0.10 mJ/) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.

RESULTS

High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.

CONCLUSION

This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.

摘要

目的

本随机对照试验旨在比较高剂量与低剂量体外冲击波疗法（ESWT）对老年骨关节炎患者免疫系统激活和调节的影响。

方法

120例65岁及以上的膝骨关节炎患者将被随机分配，分别接受高剂量（0.25 mJ/）或低剂量（0.10 mJ/）的ESWT治疗，每周一次，共4周。在基线、干预后4周和1个月随访时测量血清细胞因子、刺激的免疫细胞亚群和T调节细胞。

结果

在老年骨关节炎患者中，高剂量ESWT与低剂量ESWT相比，可能主要导致促炎细胞因子增加和免疫抑制性T调节细胞减少。

结论

本研究将为ESWT给药方案及其不同的免疫调节作用提供证据，可为老年人群肌肉骨骼疾病的最佳治疗提供指导。