减毒痘苗病毒AS株治疗晚期腺癌的临床试验。两例报告。
Clinical trial of attenuated vaccinia virus AS strain in the treatment of advanced adenocarcinoma. Report on two cases.
作者信息
Arakawa S, Hamami G, Umezu K, Kamidono S, Ishigami J, Arakawa S
出版信息
J Cancer Res Clin Oncol. 1987;113(1):95-8. doi: 10.1007/BF00389974.
Abstract
Two cases of advanced adenocarcinoma treated with attenuated vaccinia virus AS strain are reported. One was a primary lung adenocarcinoma with metastatic lesions in brain, right kidney, and rib. The other was a left renal adenocarcinoma with multiple lung and vertebral metastases. In both patients, good antitumor effects against lung and bone lesions were obtained, respectively, and no adverse reactions were noted. Therefore, treatment of patients with AS vaccinia virus appears to suppress the growth of tumor cells without adverse effects on normal human cells. This is the first report to describe the effects of attenuated vaccinia virus AS strain on human cancer.
摘要
报告了两例用减毒痘苗病毒AS株治疗的晚期腺癌病例。一例是原发性肺腺癌，脑、右肾和肋骨有转移病灶。另一例是左肾腺癌，有多处肺和脊柱转移。在这两名患者中，分别对肺部和骨病变取得了良好的抗肿瘤效果，且未观察到不良反应。因此，用AS痘苗病毒治疗患者似乎能抑制肿瘤细胞生长，而对正常人体细胞无不良影响。这是首篇描述减毒痘苗病毒AS株对人类癌症作用的报告。
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