减毒痘苗病毒AS株对N-甲基-N'-硝基-N-亚硝基胍诱导的大鼠胃癌的影响
The effect of attenuated vaccinia virus AS strain on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancer in rats.
作者信息
Arakawa S, Fukai K
出版信息
J Cancer Res Clin Oncol. 1983;105(2):117-26. doi: 10.1007/BF00406921.
Abstract
The effect of vaccinia virus on MNNG-induced gastric cancer in rats was studied. Subcutaneous inoculation of the highly attenuated vaccinia virus AS strain at intervals of 3 days from the beginning of the experiment showed prominent antitumor activity not only against adenocarcinoma induced by MNNG in the glandular stomach but also against squamous cell carcinoma in the forestomach. Both UV-inactivated vaccinia virus and the DI strain of mammalian pathogenic vaccinia virus, from which the AS strain originated, showed no antitumor effect.
摘要
研究了痘苗病毒对大鼠甲基硝基亚硝基胍（MNNG）诱导的胃癌的影响。从实验开始每隔3天皮下接种高度减毒的痘苗病毒AS株，结果显示其不仅对MNNG诱导的腺胃腺癌有显著的抗肿瘤活性，而且对前胃鳞状细胞癌也有抗肿瘤活性。紫外线灭活的痘苗病毒以及AS株所源自的哺乳动物致病性痘苗病毒DI株均未显示出抗肿瘤作用。
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