Zhang Tao, Miao Yong Chang
Department of Gastrointestinal Surgery, Bengbu Medical College Lianyungang Clinical College, The Second People's Hospital of Lianyungang, Lianyungang, Lianyungang, Jiangsu, China.
Front Oncol. 2023 Dec 22;13:1260796. doi: 10.3389/fonc.2023.1260796. eCollection 2023.
To investigate the impact of preoperative systemic immune inflammatory index (SII) on the clinical prognosis of patients undergoing colorectal cancer (CRC) surgery.
One hundred and sixty CRC patients who underwent surgical treatment in our gastrointestinal surgery department from January 2019 to May 2023 were collected. ROC curves were applied to determine the sensitivity and specificity of SII, determine the optimal cut-off value into low SII and high SII groups, compare the clinicopathological data of SII patients in the two groups, and analyze the postoperative survival of patients in the two groups using Kaplan-Meier and Log-rank methods. Univariate and multifactor COX proportional risk regression models were used to analyze clinical prognostic factors.
The ROC curve showed that the area under the curve of SII for the evaluation of OS in CRC patients was 0.859, and the best cut-off value was 513.53. There was statistical significance (P < 0.05) in terms of tissue grading and diabetes mellitus in both groups. The Kaplan-Meier survival curves showed that the overall survival rates of the SII<513.53 group and the SII≥513.53 group were 50.88% (29/57) and 32.04% (33/103), and the overall survival rate of the SII<513.53 group was significantly higher than that of the SII≥513.53 group, and the difference was statistically significance (χ2 = 8.375, P=0.004). COX proportional risk regression showed that TNM stage, lymph node metastases, anastomotic fistula and SII were independent risk factors affecting postoperative survival in patients with CRC.
Preoperative SII is an independent prognostic factor for CRC, which is simple, convenient, and non-invasive, and can be used to predict the prognosis of CRC patients.
探讨术前全身免疫炎症指数（SII）对结直肠癌（CRC）手术患者临床预后的影响。
收集2019年1月至2023年5月在我院胃肠外科接受手术治疗的160例CRC患者。应用受试者工作特征（ROC）曲线确定SII的敏感性和特异性，确定SII的最佳截断值，将患者分为低SII组和高SII组，比较两组患者的临床病理资料，并采用Kaplan-Meier法和Log-rank检验分析两组患者的术后生存情况。采用单因素和多因素COX比例风险回归模型分析临床预后因素。
ROC曲线显示，SII评估CRC患者总生存期（OS）的曲线下面积为0.859，最佳截断值为513.53。两组患者在组织分级和糖尿病方面差异有统计学意义（P<0.05）。Kaplan-Meier生存曲线显示，SII<513.53组和SII≥513.53组的总生存率分别为50.88%（29/57）和32.04%（33/103），SII<513.53组的总生存率显著高于SII≥513.53组，差异有统计学意义（χ2=8.375，P=0.004）。COX比例风险回归分析显示，TNM分期、淋巴结转移、吻合口瘘和SII是影响CRC患者术后生存的独立危险因素。
术前SII是CRC的独立预后因素，简单、方便、无创，可用于预测CRC患者的预后。
