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人类胎儿睾丸中的5α-还原雄激素。

5 alpha-reduced androgens in the human fetal testis.

作者信息

George F W, Carr B R, Noble J F, Wilson J D

出版信息

J Clin Endocrinol Metab. 1987 Mar;64(3):628-30. doi: 10.1210/jcem-64-3-628.

DOI:10.1210/jcem-64-3-628
PMID:3818894
Abstract

The androgen content was measured in testes from 34 male and in ovaries from 30 female embryos that varied in age from less than 12 to approximately 20 weeks. The 5 alpha-reduced androgens dihydrotestosterone and 3 alpha-androstanediol were found in testes at a level of about a 30th of that of testosterone at all ages examined, whereas very little or no testosterone, androstenedione, or either of the 5 alpha-reduced androgens were detected in the ovaries. Whether dihydrotestosterone plays a role in the development of the testes is unknown.

摘要

对34例雄性胚胎和30例雌性胚胎的睾丸及卵巢中的雄激素含量进行了测定,这些胚胎的年龄从不到12周至约20周不等。在所检测的各个年龄段,睾丸中均发现5α-还原雄激素双氢睾酮和3α-雄烷二醇,其水平约为睾酮的1/30,而在卵巢中未检测到或仅检测到极少量的睾酮、雄烯二酮或5α-还原雄激素中的任何一种。双氢睾酮是否在睾丸发育中发挥作用尚不清楚。

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5 alpha-reduced androgens in the human fetal testis.人类胎儿睾丸中的5α-还原雄激素。
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引用本文的文献

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Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production.邻苯二甲酸盐在体外会损害人类胎儿睾丸中的生殖细胞发育,而不会改变睾酮的产生。
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Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol.有袋类动物前列腺的形成是由睾丸雄激素5α-雄烷-3α,17β-二醇介导的。
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