Xu Fang, Hu Xin, Li Shu-Ling
Fang Xu, Department of ICU, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, P. R. China.
Xin Hu, Electrocardiogram Room, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, P. R. China.
Pak J Med Sci. 2024 Jan-Feb;40(1Part-I):145-149. doi: 10.12669/pjms.40.1.7550.
To evaluate the accuracy of serum CRP and IL-6 assays combined with the pancreatitis activity scoring system (PASS) in assessing the severity of patients with acute pancreatitis (AP).
This was a retrospective study of 223 patients with AP admitted to Baoding Lianchi District People's Hospital between February 2021 and 2023. They were classified into three categories: mild AP (MAP), moderate severe AP (MSAP) and severe AP (SAP). The differences, accuracy and sensitivity of the individual assays, and the three in combination, were compared and analysed in the three groups.
PASS scores, IL-6 and CRP levels were significantly higher in the SAP and MSAP groups compared to those in the MAP group, with statistically significant differences between the three groups. Multi-factorial logistic regression analysis suggested that PASS, IL-6 and CRP were correlated indicators of AP severity. The combination of the three assays was higher than that of the PASS score, IL-6 and CRP alone, suggesting optimal diagnostic efficacy when the three assays were combined. Moreover, the levels of PASS score, IL-6 and CRP showed a positive correlation with the degree of disease severity.
The serum CRP, IL-6 and PASS scores were significantly elevated in AP patients and showed a positive correlation with disease severity, all of which are beneficial for the diagnosis of AP. PASS is superior to CRP and IL-6 in the assessment of AP. The combination of the three assays can achieve a far superior diagnostic efficacy to that of the individual index assays.
评估血清C反应蛋白（CRP）和白细胞介素-6（IL-6）检测联合胰腺炎活动评分系统（PASS）在评估急性胰腺炎（AP）患者严重程度方面的准确性。
这是一项对2021年2月至2023年期间入住保定市莲池区人民医院的223例AP患者的回顾性研究。他们被分为三类：轻度AP（MAP）、中度重症AP（MSAP）和重症AP（SAP）。比较并分析了三组中各检测指标单独及联合检测时的差异、准确性和敏感性。
与MAP组相比，SAP组和MSAP组的PASS评分、IL-6和CRP水平显著更高，三组间差异有统计学意义。多因素逻辑回归分析表明，PASS、IL-6和CRP是AP严重程度的相关指标。三项检测联合使用时高于单独使用PASS评分、IL-6和CRP，表明三项检测联合时具有最佳诊断效能。此外，PASS评分、IL-6和CRP水平与疾病严重程度呈正相关。
AP患者血清CRP、IL-6和PASS评分显著升高，且与疾病严重程度呈正相关，所有这些都有助于AP的诊断。在评估AP方面，PASS优于CRP和IL-6。三项检测联合可实现远优于单个指标检测方法的诊断效能。
