Department of Pharmaceutical Biochemistry, Division of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Second Department of General and Oncological Surgery, Faculty of Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
Genes (Basel). 2022 Feb 1;13(2):290. doi: 10.3390/genes13020290.
In the course of acute pancreatitis, interleukin-6 plays an important role as a mediator in the inflammatory response. The course of inflammatory disease is associated with intensive oxidative stress, which may activate transcription factors leading to gene-expression changes. Isoenzymes of superoxide dismutase are involved in the defense against free radicals. This study aimed to evaluate changes in IL-6 concentration and the concentration/activity of superoxide dismutase isoenzymes (SOD1, SOD2, and SOD3) in the blood of patients with acute pancreatitis (AP) in terms of rs1800795 polymorphism in the gene. In the smoking AP patients group with the GC and GG genotypes, the plasma SOD1 concentration was significantly higher ( = 0.0146 and = 0.0250, respectively) than in patients with CC genotype for SNP rs1800795 in the gene. An increase in SOD1 concentration in erythrocytes of AP patients with GC genotypes was also demonstrated compared to the individuals from the group with GG genotype ( = 0.0408). Furthermore, a positive correlation between IL-6 and SOD1 concentrations in the plasma of AP patients with GC genotype for SNP rs1800795 was shown. These results indicate that SOD1 may play a protective role against oxidative damage induced by inflammation in the group of AP patients with GC genotype.
在急性胰腺炎的发病过程中，白细胞介素-6 作为炎症反应中的一种重要介质发挥作用。炎症性疾病的过程与强烈的氧化应激有关，这可能会激活转录因子，导致基因表达的变化。超氧化物歧化酶的同工酶参与了自由基的防御。本研究旨在评估急性胰腺炎（AP）患者血液中白细胞介素-6 浓度以及超氧化物歧化酶同工酶（SOD1、SOD2 和 SOD3）的浓度/活性变化，以 rs1800795 基因中的多态性为基础。在携带 GC 和 GG 基因型的吸烟 AP 患者组中，与携带 CC 基因型的患者相比，SNP rs1800795 处的血浆 SOD1 浓度显著更高（=0.0146 和=0.0250）。与 GG 基因型的个体相比，携带 GC 基因型的 AP 患者的红细胞中 SOD1 浓度也增加（=0.0408）。此外，还显示了携带 SNP rs1800795 的 GC 基因型的 AP 患者血浆中 IL-6 和 SOD1 浓度之间存在正相关。这些结果表明，在携带 GC 基因型的 AP 患者中，SOD1 可能在炎症诱导的氧化损伤中发挥保护作用。
