Department of Pathology, Centre for Foetal and Perinatal Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Fetal Pediatr Pathol. 2024 Mar-Apr;43(2):94-110. doi: 10.1080/15513815.2023.2301448. Epub 2024 Jan 10.
Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified procedure to provide maximum diagnostic utility in brain tissue biopsies.
Twenty newborns underwent postmortem minimally invasive tissue sampling of the brain through the anterior fontanelle and posterior approach, using the engraved lines on the needle labeled from mark 0 to 13. The cores were correlated with conventional autopsy findings.
Meninges were best obtained at marks 0 and 1 from the anterior fontanelle and mark 1 from posterior fontenelle in 85% of cases. Periventricular brain parenchyma was best obtained from mark 3 and mark 1 from anterior and posterior fontanel, respectively in 90% cases. The sampling success in obtaining brain cores was 100%.
This modified technique increases the yield of meninges and brain tissue in newborns and aids in diagnosis.
使用 Bard Monopty 针对新生儿进行微创脑组织取样，有助于通过获取相关脑核来诊断各种神经疾病。我们设计了一种改良的程序，以在脑组织活检中提供最大的诊断效用。
二十名新生儿通过前囟门和后入路进行微创脑组织取样，使用标记从 0 到 13 的针上的刻线。将这些核心与传统的尸检结果进行了比较。
85%的情况下，从前囟门的 0 号和 1 号标记以及后囟门的 1 号标记处获得的脑膜最佳；90%的情况下，从前囟门的 3 号和 1 号标记以及后囟门的 1 号标记处获得的脑室周围脑实质最佳。获得脑核的采样成功率为 100%。
这种改良技术可提高新生儿脑膜和脑组织的产量，有助于诊断。
