Wu Yanbei, Xin Mengmeng, Pham Quynhchi, Gao Yu, Huang Haiqiu, Jiang Xiaojing, Li Robert W, Yu Liangli, Luo Yaguang, Wang Jing, Wang Thomas T Y
China-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology & Business University, Beijing 100084, China.
Diet Genomics and Immunology Laboratory, BHNRC, ARS, USDA, Beltsville, MD 20705, USA.
Foods. 2023 Dec 26;13(1):85. doi: 10.3390/foods13010085.
Red cabbage (RC), a cruciferous vegetable rich in various bioactive substances, can significantly reduce the risk factors of several non-communicable diseases, but the mechanism underlying the biological effects of RC remains unclear. Furthermore, mechanisms that operate through the regulation of gut microbiota also are not known. Given the relationships between diet, gut microbiota, and health, a diet-induced mice obesity model was used to elucidate the influence of RC on gut microbial composition and bacteria-bacteria interactions in mice. After 24 h of dietary intervention, a high-fat (HF) diet with the intake of RC led to increased Firmicutes/Bacteroidetes (F/B) ratios in the feces of mice. RC also reduced the relative abundance of , , and in mice fed a low-fat (LF) diet. After 8-weeks of dietary intervention, RC significantly changed the structure and the ecological network of the gut microbial community. Particularly, RC inhibited an HF-diet-induced increase in in mice, and this genus was positively correlated with body weight, low-density lipoprotein level, and fecal bile acid of mice. Unclassified , specifically increased via RC consumption, were also found to negatively correlate with hepatic free cholesterol levels in mice. Overall, our results demonstrated that RC modulating gut microbial composition and interactions are associated with the attenuation of HF-diet-induced body weight gain and altered cholesterol metabolism in mice.
红甘蓝（RC）是一种富含多种生物活性物质的十字花科蔬菜，可显著降低多种非传染性疾病的风险因素，但其生物效应的潜在机制仍不清楚。此外，通过调节肠道微生物群发挥作用的机制也尚不明确。鉴于饮食、肠道微生物群与健康之间的关系，我们使用饮食诱导的小鼠肥胖模型来阐明RC对小鼠肠道微生物组成和细菌-细菌相互作用的影响。经过24小时的饮食干预，摄入RC的高脂（HF）饮食导致小鼠粪便中厚壁菌门/拟杆菌门（F/B）比值增加。RC还降低了低脂（LF）饮食喂养小鼠中[此处原文缺失具体菌属名称]、[此处原文缺失具体菌属名称]和[此处原文缺失具体菌属名称]的相对丰度。经过8周的饮食干预，RC显著改变了肠道微生物群落的结构和生态网络。特别是，RC抑制了HF饮食诱导的小鼠中[此处原文缺失具体菌属名称]的增加，且该菌属与小鼠体重、低密度脂蛋白水平和粪便胆汁酸呈正相关。未分类的[此处原文缺失具体菌属名称]，经RC摄入后特异性增加，也被发现与小鼠肝脏游离胆固醇水平呈负相关。总体而言，我们的结果表明，RC调节肠道微生物组成和相互作用与减轻HF饮食诱导的小鼠体重增加及改变胆固醇代谢有关。
