SIRT7 在糖脂代谢中的新兴作用。
The Emerging Role of SIRT7 in Glucose and Lipid Metabolism.
机构信息
Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
出版信息
Cells. 2023 Dec 25;13(1):48. doi: 10.3390/cells13010048.
Sirtuins (SIRT1-7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging. SIRT7 is the least well-studied member of the sirtuins, but accumulating evidence has shown that SIRT7 plays critical roles in the regulation of glucose and lipid metabolism by modulating many target proteins in white adipose tissue, brown adipose tissue, and liver tissue. This review focuses on the emerging roles of SIRT7 in glucose and lipid metabolism in comparison with SIRT1 and SIRT6. We also discuss the possible implications of SIRT7 inhibition in the treatment of metabolic diseases such as type 2 diabetes and obesity.
Sirtuins（哺乳动物中的 SIRT1-7）是一组 NAD+-依赖性赖氨酸去乙酰化酶和去酰基酶，它们调节多种生物过程，包括代谢、应激反应和衰老。SIRT7 是 sirtuins 中研究最少的成员，但越来越多的证据表明，SIRT7 通过调节白色脂肪组织、棕色脂肪组织和肝组织中的许多靶蛋白，在调节葡萄糖和脂质代谢中发挥关键作用。本综述重点介绍了 SIRT7 在葡萄糖和脂质代谢中的新兴作用，并与 SIRT1 和 SIRT6 进行了比较。我们还讨论了 SIRT7 抑制在治疗 2 型糖尿病和肥胖等代谢疾病方面的可能意义。
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