College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Republic of Korea.
CHlabs Corporation, Seoul 07249, Republic of Korea.
Nutrients. 2023 Dec 23;16(1):55. doi: 10.3390/nu16010055.
(cassia) is a tropical aromatic evergreen tree of the Lauraceae family well known for its fragrance and spicy flavor and widely used in Asian traditional medicine. It has recently garnered attention for its diverse potential health benefits, including anti-inflammatory, anti-cancer, and anti-diabetic properties. However, the gastroprotective effect of , particularly against ethanol-induced gastric damage, remains unclear. We investigated the potential gastroprotective property of and the underlying mechanisms of action in a rat model of ethanol-induced gastric injury. To assess its effectiveness, rats were fed for a 14-day period prior to inducing gastric damage by oral administration of ethanol. Our results indicated that pre-treatment with mitigated ethanol-induced gastric mucosal lesions and bleeding. Reduced gastric acid secretion and expression of acid secretion-linked receptors were also observed. Additionally, pretreatment with led to decreased levels of inflammatory factors, including TNF-α, p-p65, and IκBα. Notably, upregulated the expressions of HO1 and HSP90, with particular emphasis on the enhanced expression of PAS and MUC, the crucial gastric mucosa defense molecules. These findings suggest that has protective effects on the gastric mucosa and can effectively reduce oxidative stress and inflammation.
（决明子）是樟科热带芳香常绿乔木，因其香味和辛辣口感而闻名，广泛应用于亚洲传统医学。它最近因其多种潜在的健康益处而受到关注，包括抗炎、抗癌和抗糖尿病特性。然而，（决明子）对胃的保护作用，特别是对乙醇诱导的胃损伤的保护作用，尚不清楚。我们在乙醇诱导的大鼠胃损伤模型中研究了（决明子）的潜在胃保护作用及其作用机制。为了评估其有效性，在通过口服乙醇诱导胃损伤之前，大鼠用（决明子）喂养 14 天。我们的结果表明，（决明子）预处理减轻了乙醇诱导的胃黏膜损伤和出血。还观察到胃酸分泌减少和与胃酸分泌相关的受体表达减少。此外，（决明子）预处理导致炎症因子水平降低，包括 TNF-α、p-p65 和 IκBα。值得注意的是，（决明子）上调了 HO1 和 HSP90 的表达，特别是 PAS 和 MUC 的表达增强，PAS 和 MUC 是胃黏膜防御的关键分子。这些发现表明（决明子）对胃黏膜具有保护作用，可有效减轻氧化应激和炎症。
