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The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.1990 年至 2017 年全球 195 个国家和地区胃食管反流病的全球、区域和国家负担：2017 年全球疾病负担研究的系统分析。
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):561-581. doi: 10.1016/S2468-1253(19)30408-X. Epub 2020 Mar 13.
2
The global burden of gastro-oesophageal reflux disease: more than just heartburn and regurgitation.胃食管反流病的全球负担：不止烧心和反流
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):519-521. doi: 10.1016/S2468-1253(20)30002-9. Epub 2020 Mar 13.
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Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.基于接受利伐沙班或阿司匹林的患者的大型多年随机试验的质子泵抑制剂安全性。
Gastroenterology. 2019 Sep;157(3):682-691.e2. doi: 10.1053/j.gastro.2019.05.056. Epub 2019 May 29.
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Proton pump inhibitors therapy and the risk of pneumonia: a systematic review and meta-analysis of randomized controlled trials and observational studies.质子泵抑制剂治疗与肺炎风险：随机对照试验和观察性研究的系统评价和荟萃分析。
Expert Opin Drug Saf. 2019 Mar;18(3):163-172. doi: 10.1080/14740338.2019.1577820. Epub 2019 Feb 22.
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PPIs Are Not Responsible for Elevating Cardiovascular Risk in Patients on Clopidogrel-A Systematic Review and Meta-Analysis.质子泵抑制剂不会增加接受氯吡格雷治疗患者的心血管风险——一项系统评价与荟萃分析
Front Physiol. 2018 Nov 19;9:1550. doi: 10.3389/fphys.2018.01550. eCollection 2018.
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Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial.埃索美拉唑和阿司匹林在 Barrett 食管（AspECT）中的应用：一项随机析因试验。
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The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association.质子泵抑制剂长期使用的风险和益处：美国胃肠病学会的专家评论和最佳实践建议。
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Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis.全球胃食管反流症状的患病率及危险因素：一项荟萃分析。
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胃食管反流病药物治疗的副作用：当前争议

Side effects of drug treatments for gastro-oesophageal reflux disease: current controversies.

作者信息

Dhar Anjan, Maw Frances, Dallal Helen Jane, Attwood Stephen

机构信息

Gastroenterology, County Durham & Darlington NHS Foundation Trust, Darlington, UK.

Pharmacy, County Durham and Darlington NHS Foundation Trust, Darlington, Darlington, UK.

出版信息

Frontline Gastroenterol. 2020 Aug 12;13(1):45-49. doi: 10.1136/flgastro-2019-101386. eCollection 2022.

DOI:10.1136/flgastro-2019-101386
PMID:34966532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8666855/
Abstract

The two main drugs used in the treatment of gastro-oesophageal reflux disease are proton pump inhibitors and histamine-2 receptor antagonists and both these agents have been implicated in a number of adverse effects, leading to considerable controversies related to their long-term use. This paper is aimed at a critical review of the published literature and the clinical significance of these reported side effects, most of which are associations rather than causal.

摘要

治疗胃食管反流病的两种主要药物是质子泵抑制剂和组胺-2受体拮抗剂，这两种药物都与一些不良反应有关，导致了与其长期使用相关的诸多争议。本文旨在对已发表文献以及这些报告的副作用的临床意义进行批判性综述，其中大多数是关联而非因果关系。