Ji Linbao, Zhang Lian, Liu Hu, Shen Jiakun, Zhang Yu, Lu Lin, Zhang Xiujun, Ma Xi
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Front Nutr. 2022 Aug 17;9:965310. doi: 10.3389/fnut.2022.965310. eCollection 2022.
can secret a variety of substances to improve human and animal gut health inhibiting the proliferation of pathogenic bacteria. In this study, a fast-growing and stress-resistant strain of () were isolated, which showed a strong antibacterial activity to K88, ATCC14028, and ATCC25923 . studies showed that can significantly improve the average daily gain (ADG) using an AA broiler model. Dietary improved the intestinal morphology. The villus height of jejunum and ileum were significantly increased. The concentration of malondialdehyde (MDA) in the ileal mucosa was significantly reduced in treatment group, which suggested the oxidative stress of the ileum was significantly relieved. Though the β diversity of treatments was not significantly, improved the composition of intestinal microbes, especially at the level of caecum genus, the dominant genus was changed from to , which indicated the change of intestinal carbohydrate nutrition. In conclusion, these data indicate that the M6 shows a probiotic potential to improve intestinal health altering gut microbiota.
能够分泌多种物质来改善人和动物的肠道健康，抑制病原菌的增殖。在本研究中，分离出了一种生长迅速且抗逆的（）菌株，它对K88、ATCC14028和ATCC25923表现出强大的抗菌活性。研究表明，使用AA肉鸡模型，（）能显著提高平均日增重（ADG）。日粮（）改善了肠道形态。空肠和回肠的绒毛高度显著增加。在（）处理组中，回肠黏膜中丙二醛（MDA）的浓度显著降低，这表明回肠的氧化应激得到了显著缓解。虽然处理组的β多样性不显著，但（）改善了肠道微生物的组成，尤其是在盲肠属水平，优势属从（）变为（），这表明肠道碳水化合物营养发生了变化。总之，这些数据表明，（）M6具有通过改变肠道微生物群来改善肠道健康的益生菌潜力。
