Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Analyst. 2018 Sep 24;143(19):4526-4536. doi: 10.1039/c8an01046c.
There are thousands of lipid species existing in cells, which belong to eight different categories. Lipids are the essential building blocks of cells. Recent studies have started to unveil the important functions of lipids in regulating cell metabolism. However, we are still at a very early stage in fully understanding the physiological and pathological functions of lipids. The application of lipidomics for studying lipid metabolism can provide a direct readout of the cellular status and broadens our understanding of the mechanisms that underpin metabolic disease states. This review provides an introduction to lipid metabolism and its role in modulating homeostasis and immunity. We also describe representative applications of lipidomics for studying lipid metabolism in inflammation-related diseases.
细胞中存在数千种脂质种类，它们属于八个不同的类别。脂质是细胞的基本组成部分。最近的研究开始揭示脂质在调节细胞代谢中的重要功能。然而，我们在充分了解脂质的生理和病理功能方面仍处于非常早期的阶段。脂质组学在研究脂质代谢中的应用可以提供细胞状态的直接读数，并拓宽我们对支持代谢疾病状态的机制的理解。本文综述了脂质代谢及其在调节内稳态和免疫中的作用。我们还描述了脂质组学在研究炎症相关疾病中脂质代谢的代表性应用。
