Bress Jennifer N, Meyer Alexandria, Proudfit Greg Hajcak
Stony Brook University.
Dev Psychopathol. 2015 Nov;27(4 Pt 1):1285-94. doi: 10.1017/S0954579414001400.
Feedback negativity (FN) is an event-related potential elicited by monetary reward and loss; it is thought to relate to reward-related neural activity and has been linked to depression in children and adults. In the current study, we examined the stability of FN, and its relationship with depression in adolescents, over 2 years in 45 8- to 13-year-old children. From Time 1 to Time 2, FN in response to monetary loss and in response to monetary gain showed moderate to strong reliability (rs = .64 and .67, respectively); these relationships remained significant even when accounting for related variables. FN also demonstrated high within-session reliability. Moreover, the relationship between a blunted FN and greater depression observed at Time 1 was reproduced at Time 2, and the magnitude of FN at Time 1 predicted depressive symptomatology at Time 2. These findings are consistent with the hypothesis that FN and its relationship with depression remain consistent over the course of development, and that FN may prospectively predict later depressive symptomatology. The current results suggest that FN may be suitable as a biomarker of depressive symptoms during adolescence.
反馈负波（FN）是一种由金钱奖励和损失引发的事件相关电位；它被认为与奖励相关的神经活动有关，并且与儿童和成人的抑郁症有关。在本研究中，我们对45名8至13岁儿童进行了为期2年的研究，考察了FN的稳定性及其与青少年抑郁症的关系。从时间1到时间2，对金钱损失和金钱收益的FN表现出中等至高度的可靠性（rs分别为0.64和0.67）；即使考虑相关变量，这些关系仍然显著。FN在会话内也表现出高可靠性。此外，在时间1观察到的FN减弱与更严重的抑郁之间的关系在时间2再次出现，并且时间1的FN大小预测了时间2的抑郁症状。这些发现与以下假设一致，即FN及其与抑郁症的关系在发育过程中保持一致，并且FN可能前瞻性地预测后期的抑郁症状。目前的结果表明，FN可能适合作为青少年抑郁症状的生物标志物。
