Nakajima M, Atsumi K, Kifune K, Miura K, Kanamaru H
Jpn J Surg. 1986 Nov;16(6):418-24. doi: 10.1007/BF02470609.
Chitin is an absorbable suture material with suitable mechanical properties. Tissue reaction is not specific and the good healing which ensued provided evidence for a satisfactory biocompatibility. Toxicity tests, including acute toxicity, pyrogenicity, mutagenicity were negative in all respects. The chitin suture was absorbed in about four months in rat muscles. The persistence of the tensile strength of the chitin was better than Dexon (TM) or catgut in bile, urine and pancreatic juice but weakening occurred early in the presence of gastric juice. Application in 132 patients proved satisfactory. Adverse effects were nil.
几丁质是一种具有合适机械性能的可吸收缝合材料。组织反应不具特异性，随后出现的良好愈合为令人满意的生物相容性提供了证据。包括急性毒性、热原性、致突变性在内的毒性试验在各方面均呈阴性。几丁质缝线在大鼠肌肉中约四个月被吸收。几丁质的抗张强度在胆汁、尿液和胰液中比聚乙交酯（商标名）或肠线保持得更好，但在胃液存在的情况下会较早减弱。在132例患者中的应用证明效果令人满意。无不良反应。
