可吸收缝线在体液和pH缓冲液中的生物降解
Biodegradation of absorbable sutures in body fluids and pH buffers.
作者信息
Freudenberg S, Rewerk S, Kaess M, Weiss Christel, Dorn-Beinecke A, Post S
机构信息
Department of Surgery, University Hospital Mannheim, University of Heidelberg, Germany.
出版信息
Eur Surg Res. 2004 Nov-Dec;36(6):376-85. doi: 10.1159/000081648.
OBJECTIVE
This study measures the influence of body fluids on the loss of tensile strength of absorbable sutures in vitro.
METHODS
Nine synthetic absorbable sutures were incubated in different gastrointestinal fluids, as well as in blood and three buffers. Stretch tests were performed after days 0, 7, 14, and 21.
RESULTS
Tensile strength varied from 18.5 to 32.8 N, and elasticity varied from 9.5 to 51% of the initial length. The influence of pH, blood, and gastric juice was negligible on all sutures except PDS II. Except for Monocryl, all sutures, especially Polysorb and Vicryl, lost tensile strength much faster in bile, jejunal and pancreatic juices than in the corresponding buffers.
CONCLUSION
The biodegradation of sutures varies greatly in different body fluids independent of differences in pH.
目的
本研究在体外测量体液对可吸收缝线抗张强度损失的影响。
方法
将九种合成可吸收缝线置于不同的胃肠液、血液和三种缓冲液中进行孵育。在第0、7、14和21天后进行拉伸试验。
结果
抗张强度在18.5至32.8 N之间变化，弹性在初始长度的9.5%至51%之间变化。除PDS II外，pH值、血液和胃液对所有缝线的影响可忽略不计。除了爱惜康单股缝线，所有缝线，尤其是聚乙醇酸缝线和薇乔缝线，在胆汁、空肠液和胰液中比在相应的缓冲液中抗张强度损失得更快。
结论
缝线在不同体液中的生物降解差异很大，与pH值差异无关。
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