College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China; Jiuzhou College of Pharmacy, Yancheng Vocational Institute of Industry Technology, Yancheng 224005, PR China.
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Carbohydr Polym. 2018 Jan 15;180:304-313. doi: 10.1016/j.carbpol.2017.10.022. Epub 2017 Oct 6.
The objective of this work was to prepare a novel filament with good biocompatibility and mechanical performance which can meet the demands of surgical sutures. Bacterial cellulose nanocrystals (BCNCs) were used to reinforce regenerated chitin (RC) fibers to form BCNC/RC filaments. Mechanical performance measurements demonstrated that the strength of the BCNC/RC filament was increased dramatically over the RC analogue. A yarn made of 30 BCNC-loaded fibers also achieved satisfactory mechanical performance, with a knot-pull tensile strength of 9.8±0.6N. Enzymatic degradation studies showed the BCNC/RC materials to have good biodegradability, the rate of which can be tuned by varying the concentration of BCNCs in the yarn. The RC and the BCNC/RC materials had no cytotoxicity and can promote cell proliferation. In vivo experiments on mice demonstrated that suturing with the BCNC/RC yarn can promote wound healing without obvious adverse effects.
本工作旨在制备一种具有良好生物相容性和机械性能的新型纤维，以满足手术缝线的要求。采用细菌纤维素纳米晶体（BCNC）增强再生壳聚糖（RC）纤维，形成 BCNC/RC 纤维。力学性能测试表明，BCNC/RC 纤维的强度比 RC 纤维大幅提高。由 30 根负载 BCNC 的纤维组成的纱线也具有令人满意的力学性能，打结拉伸强度为 9.8±0.6N。酶降解研究表明，BCNC/RC 材料具有良好的生物降解性，其降解速率可以通过改变纱线中 BCNC 的浓度来调节。RC 和 BCNC/RC 材料无细胞毒性，能促进细胞增殖。小鼠体内实验表明，用 BCNC/RC 纱线缝合可促进伤口愈合，无明显不良反应。
