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生育治疗和社会经济地位对美国新生儿及新生儿后期死亡率的影响。

The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.

作者信息

Sharma Meesha, Fineman David C, Keller Roberta L, Maltepe Emin, Rinaudo Paolo F, Steurer Martina A

机构信息

Department of Pediatrics, University of California, San Francisco Benioff Children's Hospital, San Francisco, CA, USA.

Case Western Reserve University PRIME Program, School of Medicine and College of Arts and Sciences, Cleveland, OH, USA.

出版信息

J Perinatol. 2024 Feb;44(2):187-194. doi: 10.1038/s41372-024-01866-x. Epub 2024 Jan 11.

DOI:10.1038/s41372-024-01866-x
PMID:38212435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10844066/
Abstract

OBJECTIVE

To determine the association between fertility treatment, socioeconomic status (SES), and neonatal and post-neonatal mortality.

STUDY DESIGN

Retrospective cohort study of all births (19,350,344) and infant deaths from 2014-2018 in the United States. The exposure was mode of conception-spontaneous vs fertility treatment. The outcome was neonatal (<28d), and post-neonatal (28d-1y) mortality. Multivariable logistic models were stratified by SES.

RESULT

The fertility treatment group had statistically significantly higher odds of neonatal mortality (high SES OR 1.59; CI [1.5, 1.68], low SES OR 2.11; CI [1.79, 2.48]) and lower odds of post-neonatal mortality (high SES OR 0.87, CI [0.76, 0.996], low SES OR 0.6, CI [0.38, 0.95]). SES significantly modified the effect of ART/NIFT on neonatal and post-neonatal mortality.

CONCLUSIONS

Fertility treatment is associated with higher neonatal and lower post-neonatal mortality and SES modifies this effect. Socioeconomic policies and support for vulnerable families may help reduce rates of infant mortality.

摘要

目的

确定生育治疗、社会经济地位(SES)与新生儿及新生儿后期死亡率之间的关联。

研究设计

对2014 - 2018年美国所有出生的婴儿(19350344例)及婴儿死亡情况进行回顾性队列研究。暴露因素为受孕方式——自然受孕与生育治疗。结局指标为新生儿(<28天)及新生儿后期(28天至1岁)死亡率。多变量逻辑模型按社会经济地位分层。

结果

生育治疗组新生儿死亡几率在统计学上显著更高(高社会经济地位组优势比为1.59;可信区间[1.5, 1.68],低社会经济地位组优势比为2.11;可信区间[1.79, 2.48]),而新生儿后期死亡几率更低(高社会经济地位组优势比为0.87,可信区间[0.76, 0.996],低社会经济地位组优势比为0.6,可信区间[0.38, 0.95])。社会经济地位显著改变了辅助生殖技术/非侵入性产前检测对新生儿及新生儿后期死亡率的影响。

结论

生育治疗与较高的新生儿死亡率及较低的新生儿后期死亡率相关,且社会经济地位改变了这种影响。社会经济政策及对弱势家庭的支持可能有助于降低婴儿死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/4237e131e2b4/41372_2024_1866_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/2135fa67972b/41372_2024_1866_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/4e8325ca06ad/41372_2024_1866_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/4237e131e2b4/41372_2024_1866_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/2135fa67972b/41372_2024_1866_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/4e8325ca06ad/41372_2024_1866_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55f/10844066/4237e131e2b4/41372_2024_1866_Fig3_HTML.jpg

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