He Ming-Jie, Wang Yu-Jia, Ran De-Long, Fu De-Shuang, He Qing, Zhang Han-Yin, Mao Yu, Zhao Peng-Yuan, Yu Jian-Bin, Zhang Jiang-An
Department of Dermatology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
J Dermatol. 2024 Mar;51(3):403-408. doi: 10.1111/1346-8138.17100. Epub 2024 Jan 11.
Bullous pemphigoid (BP) is the most common autoimmune blistering disease, which primarily affects the elderly. However, the relationship between BP and malignancy remains controversial in traditional observational studies. The aim of this study, which included only European populations, was to assess the potential causative link between BP and 13 types of malignant tumors in a two-sample Mendelian randomization (MR) study. BP was not associated with an increased risk of developing 13 types of malignant tumors. This study did not find a causal relationship between BP and malignant tumors. However, further research is warranted to examine the generalizability of this conclusion in non-European populations.
大疱性类天疱疮（BP）是最常见的自身免疫性水疱病，主要影响老年人。然而，在传统的观察性研究中，BP与恶性肿瘤之间的关系仍存在争议。本研究仅纳入欧洲人群，旨在通过两样本孟德尔随机化（MR）研究评估BP与13种恶性肿瘤之间的潜在因果关系。BP与13种恶性肿瘤发病风险增加无关。本研究未发现BP与恶性肿瘤之间存在因果关系。然而，有必要进一步研究以检验该结论在非欧洲人群中的普遍性。
