Yamaguchi Sho T, Hatori Sena, Kotake Koki T, Zhou Zhiwen, Kume Kazuhiko, Reiter Sam, Norimoto Hiroaki
Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
PNAS Nexus. 2023 Dec 29;3(1):pgad481. doi: 10.1093/pnasnexus/pgad481. eCollection 2024 Jan.
Although diurnal animals displaying monophasic sleep patterns exhibit periodic cycles of alternating slow-wave sleep (SWS) and rapid eye movement sleep (REMS), the regulatory mechanisms underlying these regular sleep cycles remain unclear. Here, we report that in the Australian dragon exposed to constant darkness (DD), sleep behavior and sleep-related neuronal activity emerged over a 24-h cycle. However, the regularity of the REMS/SWS alternation was disrupted under these conditions. Notably, when the lizards were then exposed to 12 h of light after DD, the regularity of the sleep stages was restored. These results suggest that sleep-related neuronal activity in lizards is regulated by circadian rhythms and that the regularity of REMS and SWS cycling is influenced by daytime light exposure.
尽管表现出单相睡眠模式的昼行性动物呈现出慢波睡眠（SWS）和快速眼动睡眠（REMS）交替的周期性循环，但这些规律睡眠周期背后的调节机制仍不清楚。在此，我们报告，在持续黑暗（DD）环境下的澳大利亚鬃狮蜥中，睡眠行为和与睡眠相关的神经元活动在24小时周期内出现。然而，在这些条件下，REMS/SWS交替的规律性被破坏。值得注意的是，当蜥蜴在DD后再暴露于12小时光照下时，睡眠阶段的规律性得以恢复。这些结果表明，蜥蜴中与睡眠相关的神经元活动受昼夜节律调节，并且REMS和SWS循环的规律性受白天光照暴露的影响。
