Haarmann K, Lebkuchner F, Widmann A, Kief W, Esslinger M
Postgrad Med J. 1979;55 Suppl 1:24-7.
Oral domperidone (30 mg/day) or placebo tablets were given to 41 patients presenting with symptoms of chronic post-prandial dyspepsia, in a double blind study. The tablets were taken three times a day before meals. The first part of the study lasted four weeks and was followed by a second four week period in which domperidone was given on an open basis to all subjects. At the end of the double-blind phase all indices but one (bitter regurgitation) as well as the gastro-oesophageal reflux cluster had significantly improved on domperidone treatment while none had done so on placebo. During the subsequent open four weeks of domperidone all items improved in both study groups. No side effects were seen in any of the participants in the study.
在一项双盲研究中，对41名有慢性餐后消化不良症状的患者给予口服多潘立酮（30毫克/天）或安慰剂片剂。片剂每日三餐前服用。研究的第一阶段持续四周，随后是第二阶段，为期四周，在此期间对所有受试者开放给予多潘立酮。在双盲阶段结束时，除一项指标（苦味反流）外，所有指标以及胃食管反流组在多潘立酮治疗下均有显著改善，而安慰剂组则无改善。在随后多潘立酮治疗的四周开放期内，两个研究组的所有项目均有所改善。该研究的任何参与者均未出现副作用。
