Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Department of Neurology, Shanghai Punan Hospital, Shanghai, 200125, China.
Sleep Med. 2024 Feb;114:182-188. doi: 10.1016/j.sleep.2024.01.002. Epub 2024 Jan 6.
To characterize sleep duration and investigate its association with quality of life among Parkinson's Disease (PD) patients.
In this multicenter cross-sectional study, 970 PD patients were divided into five groups based on self-reported sleep duration: <5, ≥5 to <6, ≥6 to <7, ≥7 to ≤8, and >8 h. The quality of life was evaluated using the 39-Item Parkinson's Disease Questionnaire (PDQ-39). Multivariable linear regression analysis, subgroup analysis, and mediation analysis were conducted to examine the association between sleep duration and quality of life.
In multivariable linear regression model, patients with sleep duration (<5 h) had significantly higher PDQ-39 scores (β = 8.132, 95 % CI: 3.99 to 12.266), especially in mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort (p < 0.05). The association between sleep duration (<5 h) and worse quality of life was more pronounced in patients with higher HY stage, longer disease duration, and sleep disorders. Moreover, a significant indirect effect of sleep duration (<5 h) on quality of life was observed, with UPDRS I, UPDRS II, and UPDRS IV scores acting as mediators.
Short sleep duration (<5 h) is associated with worse quality of life among PD patients. This association was stronger among patients with advanced PD and sleep disorders, while non-motor symptoms and motor complications were identified as significant mediators in this association. These findings highlight the significance of adequate sleep duration and suitable interventions for sleep may help improve quality of life.
描述帕金森病（PD）患者的睡眠时长，并探讨其与生活质量的关系。
在这项多中心横断面研究中，970 名 PD 患者根据自我报告的睡眠时长分为五组：<5、≥5 至 <6、≥6 至 <7、≥7 至 ≤8 和 >8 h。使用 39 项帕金森病问卷（PDQ-39）评估生活质量。采用多变量线性回归分析、亚组分析和中介分析来检验睡眠时长与生活质量之间的关系。
在多变量线性回归模型中，睡眠时长<5 h 的患者 PDQ-39 评分显著更高（β=8.132，95%CI：3.99 至 12.266），尤其是在移动性、日常生活活动、情绪健康、耻辱感、社会支持、认知、交流和身体不适方面（p<0.05）。在 HY 分期较高、病程较长和存在睡眠障碍的患者中，睡眠时长<5 h 与较差的生活质量之间的关联更为明显。此外，睡眠时长<5 h 对生活质量的显著间接影响，而 UPDRS I、UPDRS II 和 UPDRS IV 评分则作为中介因素。
短睡眠时长(<5 h)与 PD 患者的生活质量较差相关。这种关联在 PD 进展和睡眠障碍患者中更为明显，而非运动症状和运动并发症被确定为这种关联的重要中介因素。这些发现强调了充足的睡眠时长的重要性，适当的睡眠干预可能有助于改善生活质量。
